{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:51:08Z","timestamp":1791395468350,"version":"4.3.3"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T00:00:00Z","timestamp":1786147200000},"content-version":"vor","delay-in-days":38,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Plasma proteomics detect multi\u2010pathway biological changes preceding dementia onset. The Dementia SomaSignal Test (dSST) is a validated 25\u2010protein score predicting 5\u2010 and 20\u2010year all\u2010cause dementia risk. Preclinical and clinical data suggest glucagon\u2010like peptide\u20101 receptor agonists may have neuroprotective effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      In a post hoc analysis of the Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity (SELECT) trial, adults \u2265 65 years with overweight\/obesity and cardiovascular disease without diabetes (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a02970) were randomized to semaglutide 2.4\u00a0mg or placebo. Non\u2010fasted serum samples at baseline and week 104 were analyzed using the dSST.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Semaglutide reduced increases in predicted dementia risk versus placebo: 2.5\u2010fold less increase in 5\u2010year risk (26.0% lower predicted event rate; odds ratio [OR] 0.74, 95% confidence interval [CI] 0.65\u20130.85) and 1.67\u2010fold less increase in 20\u2010year risk (8.8% lower; OR 0.91, 95% CI 0.88\u20130.94). It also reduced odds of higher dementia risk classification by 36% (\u03b2 \u22120.44;\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Semaglutide slowed progression of a validated proteomics\u2010based dementia risk signature.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70432","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T09:45:33Z","timestamp":1786182333000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Semaglutide attenuates a proteomics\u2010based dementia risk signature in older adults with overweight or obesity and cardiovascular disease without diabetes: A post hoc analysis of the SELECT phase 3 trial"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7793-512X","authenticated-orcid":false,"given":"Mart\u00ed","family":"Jim\u00e9nez\u2010Mausbach","sequence":"first","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2612-1797","authenticated-orcid":false,"given":"Betty M.","family":"Tijms","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam Department of Neurology Vrije Universiteit Amsterdam, Amsterdam UMC location VUmc Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clare","family":"Paterson","sequence":"additional","affiliation":[{"name":"Scientific Affairs Illumina  Boulder Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2781-0367","authenticated-orcid":false,"given":"Jan Christian","family":"Refsgaard","sequence":"additional","affiliation":[{"name":"Novo Nordisk A\/S  S\u00f8borg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,8]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.02.018"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25123"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01296\u20100"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa325"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010023\u201000550\u20107"},{"key":"e_1_2_9_7_1","first-page":"1","article-title":"Multi\u2010cohort cerebrospinal fluid proteomics identifies robust molecular signatures for Alzheimer's disease","volume":"20","author":"Cruchaga C","year":"2024","journal-title":"Alzheimers Dement"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14549"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026332"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.14313"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.12268"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010025\u201004106\u20107"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587\u2010025\u201001029\u20103"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010025\u201001263\u20104"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001573\u2010x"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201003355\u20102"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(26)00459\u20109"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2307563"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adf5681"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010019\u20100665\u20102"}],"container-title":["Alzheimer's &amp; 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