{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:51:07Z","timestamp":1791395467015,"version":"4.3.3"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":40,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Virtual reality\u2013based cognitive assessment games (VR\u2010CAGs) are an emerging digital paradigm in dementia and Alzheimer's disease research. Although multiple studies report correlations between VR\u2010CAG performance and standard neuropsychological assessments, clinical adoption remains limited, indicating that behavioral evidence alone is insufficient and that consolidated neuroimaging evidence is required. Existing neuroimaging studies link VR\u2010CAG performance to regional brain activation, volumetric change, and brainwave dynamics, but this evidence remains scattered. We conducted a scoping review of 29 neuroimaging studies on VR\u2010CAGs. Three functional neural systems were associated with VR\u2010CAG performance: the spatial map system, the response system, and the executive control system. Two VR\u2010CAG archetypes \u2013 hippocampal\u2010based and adaptive navigation \u2013 were identified. A reporting and evaluation checklist is proposed to standardize VR\u2010CAG research. Review findings indicate that VR\u2010CAGs based on allocentric and egocentric tasks may be sensitive to hippocampal health, potentially acting as candidate digital markers of dementia\u2010relevant functional cognitive decline.<\/jats:p>","DOI":"10.1002\/dad2.70434","type":"journal-article","created":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T03:09:51Z","timestamp":1786417791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Navigation performance in virtual reality\u2013based cognitive assessment games as a candidate digital cognitive marker of hippocampal vulnerability: a scoping review"],"prefix":"10.1002","volume":"18","author":[{"given":"Yesoda","family":"Bhargava","sequence":"first","affiliation":[{"name":"Cognitive Neuroscience Laboratory, Department of Biological Science BITS Pilani K. K. 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