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Here we share the design and implementation of standard operating procedures (SOPs) for the Diverse Vascular Contributions to Cognitive Impairment and Dementia (DVCID) study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>The Repository Core implements harmonized protocols for biospecimen collection and preparation. Pre\u2010, intra\u2010, and post\u2010analytical factors influencing sample integrity and data reliability are addressed. Stringent measures are applied to obtain reproducible biomarker data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Rigorous post\u2010analytical quality control ensures assay variabilities within acceptable limits. Interim analyses, presented as proof of concept, show differences in selected plasma biomarkers across sex and race\/ethnicity after covariate adjustment. These efforts establish a strong foundation for the high\u2010quality data generated in DVCID, supporting reliability of downstream analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This work demonstrates a standardized framework to enhance data comparability, aiming to inform and facilitate future multicenter biomarker studies. Interim findings also highlight the potential need for ethnoracially tailored cut\u2010offs when interpreting blood\u2010based biomarker data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70435","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T06:42:35Z","timestamp":1787035355000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Harmonizing biofluid specimen collection and biomarker quantification in Diverse Vascular Contributions to Cognitive Impairment and Dementia (DVCID) study"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1819-4144","authenticated-orcid":false,"given":"Sitong","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of California at Davis  Sacramento California USA"},{"name":"Alzheimer's Disease Research Center University of California at 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