{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:51:05Z","timestamp":1791395465860,"version":"4.3.3"},"reference-count":12,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T00:00:00Z","timestamp":1787097600000},"content-version":"vor","delay-in-days":49,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Earlier anti\u2010amyloid therapy (AAT) initiation results in improved clinical outcomes in Alzheimer's disease (AD). We sought to identify demographic, clinical, and disease\u2010related factors impacting door\u2010to\u2010treatment times (DTTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>A retrospective review of AAT data was conducted at private and academic neurological practices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      A total of 329 patients (53.2% from private versus 46.8% academic practices),\u00a0mean age\u00a073.5\u00a0\u00b1\u00a07.2 (55.3% female), with most being non\u2010Hispanic White were treated with lecanemab (81.2%) or donanemab (18.2%). DTTs were significantly reduced (\n                      <jats:italic>p\u00a0&lt;<\/jats:italic>\n                      \u00a00.05) in both practices when diagnosis was confirmed with blood\u2010based biomarkers (BBBs) as well as with greater clinic experience dosing AATs. DTT increased in patients with non\u2010Medicare insurance and was not impacted by diagnosis, referral source, apolipoprotein E genotype status, or clinic distance.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Patients with private insurance may experience greater delay in DTT, whereas BBBs may reduce DTT relative to traditional confirmatory biomarkers. DTT improves with clinic experience.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70436","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T05:49:47Z","timestamp":1787204987000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Real\u2010world determinants of time to initiation of anti\u2010amyloid treatments: comparative data from private and academic practice settings"],"prefix":"10.1002","volume":"18","author":[{"given":"Varun","family":"Mehta","sequence":"first","affiliation":[{"name":"Memory and Brain Wellness Center University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya","family":"Singh","sequence":"additional","affiliation":[{"name":"Memory and Brain Wellness Center University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordyn","family":"Kelman","sequence":"additional","affiliation":[{"name":"Abington Neurological Associates  Abington Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saanvi","family":"Nimma","sequence":"additional","affiliation":[{"name":"Abington Neurological Associates  Abington Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Lutz","sequence":"additional","affiliation":[{"name":"Abington Neurological Associates  Abington Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Schnee","sequence":"additional","affiliation":[{"name":"Memory and Brain Wellness Center University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Weisman","sequence":"additional","affiliation":[{"name":"Abington Neurological Associates  Abington Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7411-4172","authenticated-orcid":false,"given":"Michael H.","family":"Rosenbloom","sequence":"additional","affiliation":[{"name":"Memory and Brain Wellness Center University of Washington  Seattle Washington USA"},{"name":"Department of Neurology School of Medicine University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,19]]},"reference":[{"issue":"5","key":"e_1_2_8_2_1","first-page":"3698","article-title":"2024 Alzheimer's disease facts and figures","volume":"20","author":"Alzheimer's Association","year":"2024","journal-title":"Alzheimers Dement"},{"key":"e_1_2_8_3_1","first-page":"3891","article-title":"Early detection and diagnosis of Alzheimer's disease","volume":"19","author":"Mattke S","year":"2023","journal-title":"Alzheimers Dement"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000211489"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-025-13142-9"},{"issue":"10","key":"e_1_2_8_8_1","first-page":"4501","article-title":"Lecanemab: appropriate use recommendations","volume":"19","author":"Cummings J","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"5","key":"e_1_2_8_9_1","article-title":"Donanemab appropriate use recommendations","volume":"12","author":"Rabinovici GD","year":"2025","journal-title":"Alzheimers Dement"},{"issue":"2","key":"e_1_2_8_10_1","first-page":"131","article-title":"Relationship between the Montreal Cognitive Assessment and the Mini\u2010Mental State Examination","volume":"11","author":"Trzepacz PT","year":"2015","journal-title":"Alzheimers Dement"},{"key":"e_1_2_8_11_1","article-title":"Multidisciplinary adjudication model for anti\u2010amyloid therapy initiation","volume":"16","author":"Rosenbloom M","year":"2024","journal-title":"Alzheimers Dement (Amst)"},{"issue":"3","key":"e_1_2_8_12_1","first-page":"965","article-title":"Diagnostic delay in young\u2010onset Alzheimer's disease","volume":"82","author":"Kvello\u2010Alme M","year":"2021","journal-title":"Alzheimers Res Ther"},{"issue":"9","key":"e_1_2_8_13_1","first-page":"2765","article-title":"Tau deposition in early\u2010onset Alzheimer disease","volume":"143","author":"Smith R","year":"2020","journal-title":"Brain"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70436","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dad2.70436","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:57:22Z","timestamp":1791392242000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.70436"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":12,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/dad2.70436"],"URL":"https:\/\/doi.org\/10.1002\/dad2.70436","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70436"}}