{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:51:06Z","timestamp":1791395466452,"version":"4.3.3"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The anti\u2010amyloid monoclonal antibody donanemab (Kisunla\u2122) treats patients with mild cognitive impairment or mild Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This study highlights 51 patients who received at least one donanemab infusion at our memory center between October 4, 2024 and October 3, 2025.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Of the 48 patients who underwent at least one surveillance brain MRI after starting donanemab, 10 (20.8%) had ARIA detected. \u03b54 carriers more frequently displayed amyloid\u2010related imaging abnormalities (ARIA\u2010cortical superficial hemosiderosis\/microhemorrhages [ARIA\u2010H] and\/or ARIA\u2010edema\/effusion) (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.033) and ARIA\u2010H (\n                      <jats:italic>p<\/jats:italic>\n                      = 0.020) compared to \u03b54 non\u2010carriers. No patients developed symptomatic ARIA. Seven (13.7%) patients experienced infusion\u2010related side effects. Eight (15.7%) patients discontinued donanemab due to ARIA progression (5), severe infusion reactions (2), and need for anticoagulants (1).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Donanemab may be safely used in a real\u2010world setting with structured monitoring. ARIA was observed in 20.8% of patients in this implementation cohort. Larger\u2010scale multicenter data are needed to benchmark rates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70438","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T10:06:37Z","timestamp":1787047597000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Experience with donanemab over a 1\u2010year period: observations of side effects and compliance from a regional specialty medical center"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1526-4063","authenticated-orcid":false,"given":"Lisa B. E.","family":"Shields","sequence":"first","affiliation":[{"name":"Norton Neuroscience Institute Norton Healthcare Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah S.","family":"Hust","sequence":"additional","affiliation":[{"name":"Norton Neuroscience Institute Norton Healthcare Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory E.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Norton Neuroscience Institute Norton Healthcare Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Kluthe","sequence":"additional","affiliation":[{"name":"Norton Research Institute Norton Healthcare Louisville Kentucky USA"},{"name":"Department of Pediatrics University of Louisville School of Medicine  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel N.","family":"Hart","sequence":"additional","affiliation":[{"name":"Norton Neuroscience Institute Norton Healthcare Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew P.","family":"Thaliath","sequence":"additional","affiliation":[{"name":"Norton Neuroscience Institute Norton Healthcare Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon C.","family":"Dennis","sequence":"additional","affiliation":[{"name":"Norton Neuroscience Institute Norton Healthcare Louisville Kentucky USA"},{"name":"Department of Neurological Surgery University of Louisville School of Medicine  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie W.","family":"Freeman","sequence":"additional","affiliation":[{"name":"Norton Neuroscience Institute Norton Healthcare Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica F.","family":"Cain","sequence":"additional","affiliation":[{"name":"Norton Neuroscience Institute Norton Healthcare Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whoy Y.","family":"Shang","sequence":"additional","affiliation":[{"name":"Norton Neuroscience Institute Norton Healthcare Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kendall M.","family":"Wasz","sequence":"additional","affiliation":[{"name":"Norton Neuroscience Institute Norton Healthcare Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam T.","family":"Orr","sequence":"additional","affiliation":[{"name":"Norton Neuroscience Institute Norton Healthcare Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher B.","family":"Shields","sequence":"additional","affiliation":[{"name":"Norton Neuroscience Institute Norton Healthcare Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirish S.","family":"Barve","sequence":"additional","affiliation":[{"name":"Norton Neuroscience Institute Norton Healthcare Louisville Kentucky USA"},{"name":"Department of Medicine University of Louisville School of Medicine  Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-7978-0064","authenticated-orcid":false,"given":"Kenneth G.","family":"Pugh","sequence":"additional","affiliation":[{"name":"Norton Neuroscience Institute Norton Healthcare Louisville Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.1533"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2100708"},{"key":"e_1_2_10_4_1","unstructured":"U.S. Food & Drug Administration.FDA approves treatment for adults with Alzheimer's disease.2026. 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