{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:51:06Z","timestamp":1791395466447,"version":"4.3.3"},"reference-count":56,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":69,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Plasma biomarker rule\u2010out tests can be used early in the Alzheimer's disease (AD) diagnostic pathway to identify people with low likelihood of amyloid pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      A care setting\u2010agnostic cutoff for the Elecsys\n                      <jats:sup>\u00ae<\/jats:sup>\n                      Phospho\u2010Tau (181P) plasma (pT181p) immunoassay was determined and validated in two independent, diverse cohorts, representative of real\u2010world clinical practice (\n                      <jats:italic>N\u00a0<\/jats:italic>\n                      =\u00a0604;\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a0787, respectively). An additional cutoff was assessed in a subset of people reflective of primary care (\n                      <jats:italic>n\u00a0<\/jats:italic>\n                      =\u00a0312).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>At a care setting\u2010agnostic cutoff of 0.934 pg\/ml, high negative predictive value (NPV) (93.8%) and acceptable positive predictive value (PPV) (46.6%) were observed against amyloid\u2010positron emission tomography (PET). A primary care\u2010specific cutoff of 0.722 pg\/ml showed high NPV (97.9%) against amyloid\u2010PET. Amyloid positivity prevalence for each cutoff population was 22.5% and 13.1%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The pT181p immunoassay is a high\u2010performance test that may substantially help improve access to amyloid pathology testing for people requiring confirmation, potentially leading to timely clinical decisions and better outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70439","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:47:17Z","timestamp":1788936437000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Elecsys pT181p immunoassay: Clinical performance for ruling out amyloid pathology"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6202-6906","authenticated-orcid":false,"given":"Craig","family":"Ritchie","sequence":"first","affiliation":[{"name":"Scottish Brain Sciences, 3rd floor Scottish Gas Murrayfield Stadium South Stand  Edinburgh UK"},{"name":"Department of Medicine University of St. Andrews  St. Andrews Fife UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayuri","family":"Hortsch","sequence":"additional","affiliation":[{"name":"Roche Diagnostics GmbH  Penzberg Bavaria Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Quijano\u2010Rubio","sequence":"additional","affiliation":[{"name":"Roche Diagnostics International Ltd  Rotkreuz Zug Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Menzel","sequence":"additional","affiliation":[{"name":"Roche Diagnostics GmbH  Penzberg Bavaria Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imke","family":"Kirste","sequence":"additional","affiliation":[{"name":"Roche Molecular Systems, Inc.  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