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We assessed whether magnetic resonance imaging (MRI)\u2010derived measures of oxygen metabolism, oxygen extraction fraction (OEF), and cerebral metabolic rate of oxygen (CMRO\n                      <jats:sub>2<\/jats:sub>\n                      ) were associated with tau deposition in vivo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We assessed tau using\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010MK\u20106240 positron emission tomography and CMRO\n                      <jats:sub>2<\/jats:sub>\n                      \/OEF using multi\u2010echo gradient\u2010recalled echo with QQ processing, as well as pseudo\u2010continuous arterial spin\u2010labeling MRI in cognitively normal (CN) elderly and subjects with mild cognitive impairment\/AD (\n                      <jats:italic>N<\/jats:italic>\n                      \u00a0=\u00a042). Associations among imaging measures were evaluated across cortical lobes, including comparisons between regions with and without tau deposition.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Across all subjects, higher tau standardized uptake value ratio (SUVR) was associated with lower cerebral blood flow (CBF) and CMRO\n                      <jats:sub>2<\/jats:sub>\n                      . Tau SUVR was negatively associated with Montreal Cognitive Assessment scores, whereas OEF, CBF, and CMRO\n                      <jats:sub>2<\/jats:sub>\n                      were positively associated. Within subjects, CMRO\n                      <jats:sub>2<\/jats:sub>\n                      was lower in tau\u2010positive temporal regions in both CN and MCI\/AD subjects, and CBF was lower in tau\u2010positive temporal regions in CN subjects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      MRI\u2010derived CBF and CMRO\n                      <jats:sub>2<\/jats:sub>\n                      were associated with regional tau deposition, particularly in the temporal lobe, which suggests they have potential as non\u2010invasive markers of metabolic alterations accompanying tau pathology.\n                    <\/jats:p>\n                  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