{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:51:05Z","timestamp":1791395465848,"version":"4.3.3"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":48,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100006827","name":"Florida Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006827","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32HL166609"],"award-info":[{"award-number":["T32HL166609"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["T32AG081170"],"award-info":[{"award-number":["T32AG081170"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R37 NS029993"],"award-info":[{"award-number":["R37 NS029993"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>The American Heart Association's Life's Essential 8\u2122 (LE8) defines cardiovascular health (CVH) using eight behavioral and clinical metrics. We examined the association between CVH and incident dementia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We used data from 920 dementia\u2010free participants of the Northern Manhattan Study. LE8 scores (range: 0\u2013100) were calculated from information on clinical and behavioral characteristics. Dementia was adjudicated by expert clinicians using neuropsychological assessments and clinical records. We used Cox proportional hazards models to determine associations adjusting for age, sex, race\/ethnicity, education, and insurance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Mean age was 64 years, 60% of participants were female, 65% were Hispanic, and mean LE8 score was 60. Over 9 years, 175 participants developed dementia. Each 10\u2010unit decrement in LE8 score was associated with a greater risk of dementia (hazard ratio [HR]: 1.33; 95% confidence interval [CI]: 1.17\u20131.51).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>CVH is important for brain health, and our results support interventions aimed at improving CVH for prevention of dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70444","type":"journal-article","created":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T10:24:14Z","timestamp":1787048654000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Life's Essential 8\u2122 and incident dementia in an urban cohort: Findings from the Northern Manhattan Study"],"prefix":"10.1002","volume":"18","author":[{"given":"Erin\u2010Leigh","family":"Gallop","sequence":"first","affiliation":[{"name":"Evelyn McKnight Brain Institute University of Miami School of Medicine  Miami Florida USA"},{"name":"Department of Neurology University of Miami School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Kondeti","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Miami School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Gardener","sequence":"additional","affiliation":[{"name":"Evelyn McKnight Brain Institute University of Miami School of Medicine  Miami Florida USA"},{"name":"Department of Neurology University of Miami School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatjana","family":"Rundek","sequence":"additional","affiliation":[{"name":"Evelyn McKnight Brain Institute University of Miami School of Medicine  Miami Florida USA"},{"name":"Department of Neurology University of Miami School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Neurology Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchell S. V.","family":"Elkind","sequence":"additional","affiliation":[{"name":"Department of Neurology Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"},{"name":"Department of Epidemiology Mailman School of Public Health Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton B.","family":"Wright","sequence":"additional","affiliation":[{"name":"Stroke Branch, Division of Intramural Research National Institute of Neurological Disorders and Stroke National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bonnie","family":"Levin","sequence":"additional","affiliation":[{"name":"Evelyn McKnight Brain Institute University of Miami School of Medicine  Miami Florida USA"},{"name":"Department of Neurology University of Miami School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lily","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences University of Miami School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Agudelo","sequence":"additional","affiliation":[{"name":"Evelyn McKnight Brain Institute University of Miami School of Medicine  Miami Florida USA"},{"name":"Department of Neurology University of Miami School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Assuras","sequence":"additional","affiliation":[{"name":"Department of Neurology Vagelos College of Physicians and Surgeons Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Guzman","sequence":"additional","affiliation":[{"name":"Department of Neurology Icahn School of Medicine at Mount Sinai  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7528-7988","authenticated-orcid":false,"given":"Tali","family":"Elfassy","sequence":"additional","affiliation":[{"name":"Evelyn McKnight Brain Institute University of Miami School of Medicine  Miami Florida USA"},{"name":"Department of Medicine University of Miami School of Medicine  Miami Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13016"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.06.3063"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010024\u201003340\u20109"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01296\u20100"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2023.101934"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000001078"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/jaha.116.005180"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.113.000635"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1386498"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12877\u2010024\u201005547\u20104"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1376463"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.496588"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002529"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2011.548"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.str.29.2.380"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc08\u20100545"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010201370"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/014662167700100306"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1017\/s003329170002691x"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.030"},{"key":"e_1_2_8_23_1","volume-title":"American Psychiatric A, American Psychiatric Association DSMTF. 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