{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:55:36Z","timestamp":1790826936067,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["2T32AG023481"],"award-info":[{"award-number":["2T32AG023481"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG062422"],"award-info":[{"award-number":["P30AG062422"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K23AG073514"],"award-info":[{"award-number":["K23AG073514"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Amyloid\u2010targeting therapies\u00a0(ATT) require frequent magnetic resonance imaging monitoring to detect vasogenic edema and hemorrhage, i.e., amyloid\u2010related imaging abnormalities (ARIA). Neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) are potential blood\u2010based biomarkers (BBM) of ARIA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Plasma NfL and GFAP were longitudinally collected in an ATT clinic and natural log transformed. Baseline, pre\u2010ARIA, and trajectories were compared between patients with (\n                      <jats:italic>N\u00a0=<\/jats:italic>\n                      \u00a015) and without (\n                      <jats:italic>N\u00a0=<\/jats:italic>\n                      \u00a045) ARIA.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Baseline NfL and GFAP did not differ between patients with or without ARIA (ln[NfL] ECLIA 1.24\u00a0\u00b1\u00a00.38 pg\/mL vs 1.25\u00a0\u00b1\u00a00.40 pg\/mL,\n                      <jats:italic>p\u00a0=<\/jats:italic>\n                      \u00a00.77; ln[NfL] Simoa 2.87\u00a0\u00b1\u00a00.47 pg\/mL vs 2.98\u00a0\u00b1\u00a00.40 pg\/mL,\n                      <jats:italic>p\u00a0=<\/jats:italic>\n                      \u00a00.30, ln[GFAP] ECLIA 4.95\u00a0\u00b1\u00a00.36 pg\/mL vs 4.88\u00a0\u00b1\u00a00.47 pg\/mL,\n                      <jats:italic>p\u00a0=<\/jats:italic>\n                      \u00a00.69). No significant changes were seen at the timepoint preceding ARIA, and ARIA incidence made no detectable impact on biomarker trajectories.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Biobanking in treatment clinics can evaluate clinical utility of BBMs as monitoring tools. These findings do not support a strong association between NfL or GFAP and ARIA in the ATT clinic.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70446","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:06:48Z","timestamp":1790824008000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of plasma neurofilament and glial fibrillary acidic protein to predict or detect amyloid related imaging abnormalities"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1040-7819","authenticated-orcid":false,"given":"Nicholas U.","family":"Schwartz","sequence":"first","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center Department of Neurology Weill Institute for Neurosciences University of California, San Francisco  San Francisco California 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas J.","family":"Ashton","sequence":"additional","affiliation":[{"name":"Banner Sun Health Research Institute  Sun City Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Dage","sequence":"additional","affiliation":[{"name":"Department of Neurology Indiana University School of Medicine  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaancan","family":"Deniz","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center Department of Neurology Weill Institute for Neurosciences University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Connor D.","family":"Dietz","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center Department of Neurology Weill Institute for Neurosciences University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter A.","family":"Ljubenkov","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center Department of Neurology Weill Institute for Neurosciences University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Miller","sequence":"additional","affiliation":[{"name":"Edward and Pearl Fein Memory and Aging Center Department of Neurology Weill Institute for Neurosciences University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kambiz","family":"Nael","sequence":"additional","affiliation":[{"name":"Department of Radiology &amp; Biomedical Imaging Weill Institute for Neurosciences University of California, San Francisco  San Francisco California 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