{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:50:59Z","timestamp":1791532259308,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:00:00Z","timestamp":1791504000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Amyloid positron emission tomography (PET) is the reference biomarker for treatment target engagement in anti\u2010amyloid beta (A\u03b2) therapies in early symptomatic Alzheimer's disease (AD), yet global metrics may mask a regional heterogeneity of amyloid clearance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We report real\u2010world longitudinal amyloid\u2010PET data from 26 patients treated with lecanemab or donanemab for 6 months. Global Centiloids and regional standardized uptake value ratios (SUVRs) were quantified at baseline and 6 months and examined according to treatment, clinical diagnosis, and clinical stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Amyloid removal was regionally heterogeneous. Patients with mild cognitive impairment showed greater cortical amyloid reduction than those with mild dementia, while early\u2010 and late\u2010onset AD exhibited comparable clearance. Frontal, anterior cingulate, and parietal regions showed the largest SUVR reductions, whereas the occipital cortex and temporal mesial cortex were consistently spared, including in patients reaching global amyloid\u2010PET negativity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Early amyloid clearance following anti\u2010amyloid treatment is regionally heterogeneous and incompletely captured by global PET measures.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70448","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:32:33Z","timestamp":1791531153000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Regional amyloid\u2010PET clearance dynamics and anti\u2010A\u03b2 monoclonal antibody therapy: a preliminary real\u2010world study"],"prefix":"10.1002","volume":"18","author":[{"given":"Alma","family":"Ghirelli","sequence":"first","affiliation":[{"name":"Center for Alzheimer's and Related Diseases (CARD) Neurology Unit IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Neuroimaging Research Unit Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Vita\u2010Salute San Raffaele University  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giordano","family":"Cecchetti","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Diseases (CARD) Neurology Unit IRCCS San Raffaele Scientific Institute  Milan Italy"},{"name":"Neuroimaging Research Unit Division of Neuroscience IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo G.","family":"Spinelli","sequence":"additional","affiliation":[{"name":"Center for Alzheimer's and Related Diseases 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