{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:51:03Z","timestamp":1791395463152,"version":"4.3.3"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":42,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Multiple standardized uptake value ratio (SUVR) and Centiloid (CL) thresholds exist for amyloid\u2011\u03b2 (A\u03b2) positron emission tomography (PET) to classify scans as negative or positive, yet none reliably stratify brain amyloid plaque load (BAPL). This study proposes a global gray matter\u2013based SUVR\/CL model to determine amyloid status and quantitatively differentiate BAPL scores.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      Two\n                      <jats:sup>18<\/jats:sup>\n                      F\u2010Florbetaben (FBB) PET datasets were analyzed to derive SUVRs and CL values from global gray and white matter. SUVR\/CL were integrated with visual assessment and BAPL scoring, resulting in CL thresholds to distinguish amyloid status and cognitive stage. The CL thresholds were validated in an independent local cohort.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Global gray\u2010to\u2010white matter CL best stratified amyloid status and BAPL scores, yielding CL thresholds of\u00a0&lt;\u00a021 and\u00a0&gt;\u00a038 and high diagnostic accuracy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>The integrated global CL\u2013BAPL model reliably stratified amyloid positivity and BAPL level, suggesting that it could serve as a complementary tool to visual assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70449","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T10:08:11Z","timestamp":1786529291000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantification of global gray matter amyloid\u2010\u03b2 plaque from\n                    <sup>18<\/sup>\n                    F\u2010Florbetaben PET\/MRI and correlation to BAPL score in patients with cognitive impairment"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8439-9498","authenticated-orcid":false,"given":"Adam","family":"Farag","sequence":"first","affiliation":[{"name":"University Medical Imaging Toronto, Toronto Joint Dept. Medical Imaging University Health Network Mount Sinai Hospital and Women's College Hospital University of Toronto  Toronto Ontario Canada"},{"name":"Department of Medical Imaging The Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Ali","family":"Mirshahvalad","sequence":"additional","affiliation":[{"name":"University Medical Imaging Toronto, Toronto Joint Dept. Medical Imaging University Health Network Mount Sinai Hospital and Women's College Hospital University of Toronto  Toronto Ontario Canada"},{"name":"Department of Radiology Health Sciences North, Northern Ontario School of Medicine  Sudbury Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Ortega","sequence":"additional","affiliation":[{"name":"University Medical Imaging Toronto, Toronto Joint Dept. Medical Imaging University Health Network Mount Sinai Hospital and Women's College Hospital University of Toronto  Toronto Ontario Canada"},{"name":"Department of Medical Imaging The Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmela","family":"Tartaglia","sequence":"additional","affiliation":[{"name":"Memory Clinic \u2010 Krembil Brain Institute University Health Network; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Veit\u2010Haibach","sequence":"additional","affiliation":[{"name":"University Medical Imaging Toronto, Toronto Joint Dept. Medical Imaging University Health Network Mount Sinai Hospital and Women's College Hospital University of Toronto  Toronto Ontario Canada"},{"name":"Department of Medical Imaging The Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ur","family":"Metser","sequence":"additional","affiliation":[{"name":"University Medical Imaging Toronto, Toronto Joint Dept. Medical Imaging University Health Network Mount Sinai Hospital and Women's College Hospital University of Toronto  Toronto Ontario Canada"},{"name":"Department of Medical Imaging The Temerty Faculty of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010022\u201005784\u2010y"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(06)69113\u20107"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2020.26.7.888"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000001198"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.02.004"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40336\u2010015\u20100102\u20106"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.115.171595"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2014.07.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010020\u201076102\u20105"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.12.1791"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.3092"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.118.210518"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011031"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12317"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A9079"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010256"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010023\u201006279\u20100"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23922"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2023.102789"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12021\u2010011\u20109133\u2010y"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116189"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2015.2476354"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259\u2010017\u20103749\u20106"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1613\/jair.953"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101339"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.043157"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A8743"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.117.194720"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci14020132"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.01.021"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.4103\/wjnm.WJNM_5_17"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000836\u20101"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.01.13.25320481"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410290403"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-019-0478-z"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70449","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dad2.70449","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70449","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:56:53Z","timestamp":1791392213000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.70449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/dad2.70449"],"URL":"https:\/\/doi.org\/10.1002\/dad2.70449","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70449"}}