{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:50:48Z","timestamp":1791395448406,"version":"4.3.3"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T00:00:00Z","timestamp":1787356800000},"content-version":"vor","delay-in-days":52,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Accelerated brain volume loss has been observed following trials of anti\u2010amyloid beta immunotherapy (AAT); however, there is limited understanding of this paradoxical phenomenon in early\u2010onset Alzheimer's disease (EOAD) versus late\u2010onset Alzheimer's disease (LOAD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We retrospectively analyzed brain volume changes over a 1\u2010year period following initiation of AAT. Annualized rates of brain volume alteration were calculated, and linear mixed\u2010effects models were performed to assess brain volume trajectories in EOAD versus LOAD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      One hundred fourteen participants (35 with EOAD; 79 with LOAD; mean baseline MMSE: 27) were analyzed. Ventricular expansion, measuring \u223c15%\/year, and whole\u2010brain atrophy occurred in both groups. LOAD showed \u223c1.7\u00d7 greater hippocampal atrophy compared with EOAD, independent of baseline cerebral amyloid burden, though global cortical amyloid burden predicted whole\u2010brain and hippocampal atrophy (\n                      <jats:italic>p\u00a0<\/jats:italic>\n                      &lt;\u00a00.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Brain atrophy with prominent ventricular expansion occurs in early\u2010stage EOAD and LOAD following AAT. Additional studies are needed to elucidate the mechanisms and implications of this post\u2010immunotherapy effect.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70457","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T08:32:30Z","timestamp":1787387550000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Anti\u2010amyloid immunotherapy and brain volume trajectories in early\u2010onset versus late\u2010onset Alzheimer's disease"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2532-7435","authenticated-orcid":false,"given":"Rashi I.","family":"Mehta","sequence":"first","affiliation":[{"name":"Rockefeller Neuroscience Institute of West Virginia University  Morgantown West Virginia USA"},{"name":"Department of Neuroradiology West Virginia University  Morgantown West Virginia USA"},{"name":"Department of Neuroscience West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Methasit","family":"Jaisa\u2010aad","sequence":"additional","affiliation":[{"name":"Department of Neurology West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila Vieira Ligo","family":"Teixeira","sequence":"additional","affiliation":[{"name":"Rockefeller Neuroscience Institute of West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D.","family":"Worhunsky","sequence":"additional","affiliation":[{"name":"Rockefeller Neuroscience Institute of West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph E.","family":"Malone","sequence":"additional","affiliation":[{"name":"Rockefeller Neuroscience Institute of West Virginia University  Morgantown West Virginia USA"},{"name":"Department of Neurology West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Ward","sequence":"additional","affiliation":[{"name":"Rockefeller Neuroscience Institute of West Virginia University  Morgantown West Virginia USA"},{"name":"Department of Neurology West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cierra M.","family":"Keith","sequence":"additional","affiliation":[{"name":"Rockefeller Neuroscience Institute of West Virginia University  Morgantown West Virginia USA"},{"name":"Department of Neuroscience West Virginia University  Morgantown West Virginia USA"},{"name":"Department of Behavioral Medicine and Psychiatry West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly E.","family":"Phelps","sequence":"additional","affiliation":[{"name":"Rockefeller Neuroscience Institute of West Virginia University  Morgantown West Virginia USA"},{"name":"Department of Behavioral Medicine and Psychiatry West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Sharif","sequence":"additional","affiliation":[{"name":"Rockefeller Neuroscience Institute of West Virginia University  Morgantown West Virginia USA"},{"name":"Department of Behavioral Medicine and Psychiatry West Virginia University  Morgantown West Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Pockl","sequence":"additional","affiliation":[{"name":"Rockefeller Neuroscience Institute of West Virginia University  Morgantown West Virginia USA"},{"name":"Department of Medicine West Virginia University  Morgantown West Virginia 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