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Surrogate CSF biomarkers were created for I\u2010CONECT subjects using machine learning models from common NACC clinical variables. Correlations assessed associations between CSF and language markers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Lower predicted CSF amyloid beta correlated significantly with reduced syntactic complexity and shorter speech responses. Higher predicted total tau and phosphorylated tau correlated with reduced syntactic complexity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This study demonstrates novel links between language markers and fluid biomarkers, highlighting conversational language as a potential accessible, non\u2010invasive approach for early detection and monitoring of Alzheimer's pathology.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70466","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:05:55Z","timestamp":1788339955000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bridging language markers and pathology: correlations between digital speech measures and surrogate CSF biomarkers in Alzheimer's disease"],"prefix":"10.1002","volume":"18","author":[{"given":"Yijiang","family":"Pang","sequence":"first","affiliation":[{"name":"Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurology Harvard Medical School Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko H.","family":"Dodge","sequence":"additional","affiliation":[{"name":"Department of Neurology Harvard Medical School Massachusetts General Hospital  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4336-6777","authenticated-orcid":false,"given":"Jiayu","family":"Zhou","sequence":"additional","affiliation":[{"name":"University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trci.2017.01.006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fdgth.2021.702772"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.086340"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.109199"},{"key":"e_1_2_8_6_1","doi-asserted-by":"crossref","unstructured":"HoangB PangY DodgeH ZhouJ.Translingual language markers for cognitive assessment from spontaneous speech.In Interspeech 2024.2024:977\u2010981.ISCA.","DOI":"10.21437\/Interspeech.2024-1422"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200581"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1221401"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-024-01543-3"},{"key":"e_1_2_8_10_1","doi-asserted-by":"crossref","unstructured":"FarzanaS StoppaE LeowA GollanT MooreR SalmonD et\u00a0al.SLaCAD: a spoken language corpus for early Alzheimer \u2019s disease detection. In:CalzolariN KanM\u2010Y HosteV LenciA SaktiS XueN eds.Proceedings of the 2024 Joint International Conference on Computational Linguistics Language Resources and Evaluation (LREC\u2010COLING 2024) ELRA and ICCL;2024:14877\u201014897.","DOI":"10.63317\/3z47vwqvwokc"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2024.1451326"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/geront\/gnad147"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eswa.2023.121929"},{"key":"e_1_2_8_14_1","first-page":"7","article-title":"Detection of mild cognitive impairment from language markers with crossmodal augmentation","volume":"28","author":"Liu G","year":"2023","journal-title":"Pac Symp Biocomput"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2024.108606"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000279"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010151045"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2010.09.007"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11053\u2010023\u201010249\u20106"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43856-025-01263-1"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.laheal.2024.09.002"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv181"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70466","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dad2.70466","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70466","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:55:48Z","timestamp":1791392148000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.70466"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1002\/dad2.70466"],"URL":"https:\/\/doi.org\/10.1002\/dad2.70466","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"2026-01-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70466"}}