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We investigated associations of seven plasma essential trace elements, including manganese, iron, cobalt, copper, zinc, selenium, and molybdenum, with AD and all\u2010cause dementia risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed 1,737 participants from the National Alzheimer's Coordinating Center. Cross\u2010sectional analyses assessed prevalent disease; longitudinal analyses evaluated incident cases among 1,101 initially dementia\u2010free participants (median follow\u2010up: 2.05 years). Multivariable logistic regression, Cox proportional hazards models, and quantile\u2010based g\u2010computation evaluated individual and mixture effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>A simultaneous one\u2010quartile increase in the seven\u2010element mixture was associated with lower prevalent AD (odds ratio [OR]\u00a0=\u00a00.69; 95% confidence interval [CI]: 0.52\u20130.91). Longitudinally, higher plasma iron was associated with lower incident AD (hazard ratio [HR]\u00a0=\u00a00.41; 95% CI: 0.19\u20130.92, Q4 vs. Q1), while selenium predicted higher incident AD risk (HR\u00a0=\u00a02.42; 95% CI: 1.11\u20135.27, Q4 vs. Q1).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Lower plasma iron and higher plasma selenium were each associated with greater dementia risk, identifying iron and selenium as potentially modifiable factors for dementia prevention, especially in selenium\u2010replete populations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70467","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T11:43:48Z","timestamp":1787744628000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations between essential trace elements and Alzheimer's disease and related dementias"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0851-6605","authenticated-orcid":false,"given":"Xin","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger L.","family":"Albin","sequence":"additional","affiliation":[{"name":"Michigan Alzheimer Disease Center University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"},{"name":"Neurology Service &amp; GRECC VAAAHS  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Giordani","sequence":"additional","affiliation":[{"name":"Michigan Alzheimer Disease Center University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Psychiatry University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhramar","family":"Mukherjee","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Yale School of Public Health Yale University  New Heaven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry L.","family":"Paulson","sequence":"additional","affiliation":[{"name":"Michigan Alzheimer Disease Center University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly M.","family":"Bakulski","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health University of Michigan  Ann Arbor Michigan USA"},{"name":"Michigan Alzheimer Disease Center University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,26]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70235"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(24)01296\u20100"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2025.1539749"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/exposome\/osaf002"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035\u2010020\u201000189\u2010z"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(14)70117\u20106"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.02.031"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041\u2010019\u20100528\u20102"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.646518"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00300"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12302\u2010024\u201000980\u2010z"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000279"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0B013E318142774E"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.03.005"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70682"},{"key":"e_1_2_8_17_1","unstructured":"US EPA.The SW\u2010846 Compendium. 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