{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:51:06Z","timestamp":1791395466475,"version":"4.3.3"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":69,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG009740"],"award-info":[{"award-number":["U01AG009740"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["U01AG058499"],"award-info":[{"award-number":["U01AG058499"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RC2 AG036495"],"award-info":[{"award-number":["RC2 AG036495"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RC4AG039029"],"award-info":[{"award-number":["RC4AG039029"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["HRS\u201018\u2010586069C"],"award-info":[{"award-number":["HRS\u201018\u2010586069C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Whether Alzheimer's disease (AD) blood biomarker\u2013cognition associations differ across cognitive domains, analytic context, and biomarker modeling strategy in population\u2010based cohorts is unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In 1170 older adults from the Health and Retirement Study Harmonized Cognitive Assessment Protocol (HRS\u2010HCAP), we examined cross\u2010sectional (2016) and prospective (2016 to 2022) associations of blood phosphorylated tau at threonine 181 (p\u2010tau181), glial fibrillary acidic protein (GFAP), neurofilament light (NfL), and amyloid beta 42\/40 ratio (A\u03b242\/40) with memory, executive function, language, visuospatial ability, and global cognition using individual\u2010biomarker, principal component analysis\u2010derived composite, and multi\u2010biomarker panel models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      Cross\u2010sectionally, NfL and GFAP showed the broadest associations with cognitive performance. In simultaneous models of baseline\u2010adjusted follow\u2010up cognition, p\u2010tau181 was associated with lower memory (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.080,\n                      <jats:italic>q<\/jats:italic>\n                      \u00a0&lt;\u00a00.001) and global cognition (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.066,\n                      <jats:italic>q<\/jats:italic>\n                      \u00a0&lt;\u00a00.001), while GFAP was associated with lower executive function (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.047,\n                      <jats:italic>q<\/jats:italic>\n                      \u00a0=\u00a00.007), memory (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.047,\n                      <jats:italic>q<\/jats:italic>\n                      \u00a0=\u00a00.032), and global cognition (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u00a0=\u00a0\u22120.066,\n                      <jats:italic>q<\/jats:italic>\n                      \u00a0=\u00a00.002). NfL and A\u03b242\/40 were not independently associated after mutual adjustment. P\u2010tau181 also showed relative domain selectivity between memory and executive function. Relative model support differed by cognitive domain and analytic context.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>AD blood\u2010based biomarker\u2013cognition associations were domain\u2010differentiated and context\u2010dependent: Concurrent associations did not reliably indicate associations with cognition 6 years later, and only p\u2010tau181 showed formal evidence of relative memory\u2010versus\u2010executive selectivity. Exploratory pairwise comparisons highlighted p\u2010tau181 + GFAP for follow\u2010up memory and global cognition, warranting independent evaluation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70471","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:49:19Z","timestamp":1788936559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparative analyses of Alzheimer's disease blood biomarkers and cognitive domains"],"prefix":"10.1002","volume":"18","author":[{"given":"Deirdre M.","family":"O'Shea","sequence":"first","affiliation":[{"name":"Comprehensive Center for Brain Health, Department of Neurology University of Miami, Miller School of Medicine  Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James E.","family":"Galvin","sequence":"additional","affiliation":[{"name":"Comprehensive Center for Brain Health, Department of Neurology University of Miami, Miller School of Medicine  Boca Raton Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13859"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12724"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.037520"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(20)30071\u20105"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcae396"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010018\u20100058\u2010z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201023746\u20100"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001459\u2010y"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582\u2010024\u201000989\u20101"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.05.017"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591\u2010022\u201001822\u20102"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12375"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000271090.28148.24"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207675"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12614"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006171"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1017\/S135561771700100X"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13829"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwaf179"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/13872877251415367"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1198\/000313006X152649"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13652"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcad113"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.27285"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.70443"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/arclin\/acae019"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000503004"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu067"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2022.3543"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/0049124104268644"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1995.10476572"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2004.09.006"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617710001426"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.2517\u20106161.1995.tb02031.x"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcab136"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70948"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12487"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1355617721000813"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010230384"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2026.103058"}],"container-title":["Alzheimer's &amp; 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