{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:55:41Z","timestamp":1790826941167,"version":"4.1.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2016\u201002282"],"award-info":[{"award-number":["2016\u201002282"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2021\u201001861"],"award-info":[{"award-number":["2021\u201001861"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2025\u201002101"],"award-info":[{"award-number":["2025\u201002101"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2025\u201002405"],"award-info":[{"award-number":["2025\u201002405"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006636","name":"Forskningsr\u00e5det f\u00f6r h\u00e4lsa, arbetsliv och v\u00e4lf\u00e4rd","doi-asserted-by":"publisher","award":["2024\u201000210"],"award-info":[{"award-number":["2024\u201000210"]}],"id":[{"id":"10.13039\/501100006636","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Cerebral microbleeds (CMBs) represent an important magnetic resonance imaging (MRI) marker of cerebral small vessel pathology in memory\u2010clinic populations, where vascular and neurodegenerative pathologies frequently overlap.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>This cross\u2010sectional study included 747 patients from a Swedish memory clinic who underwent 3T MRI with susceptibility\u2010weighted imaging. Two readers assessed CMBs using standardized criteria. Inter\u2010 and intra\u2010observer agreement were evaluated before and after protocol refinement. CMB prevalence and burden were analyzed across diagnostic groups and by cerebrospinal fluid amyloid status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>CMBs were present in 28.6% of patients and frequently observed in subjects with mild cognitive impairment or dementia. Inter\u2010observer agreement improved from \u03ba\u00a0=\u00a00.71 to \u03ba\u00a0=\u00a00.82 after protocol refinement. Among amyloid\u2010positive patients with cognitive impairment, 11.2% exceeded proposed CMB thresholds for anti\u2010amyloid therapy eligibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Standardized CMB assessment improves reliability in memory\u2010clinic populations. Given its growing impact on treatment eligibility and safety, consistent evaluation is essential for patient management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70472","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:10:06Z","timestamp":1790824206000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cerebral microbleed assessment on MRI in a memory clinic: Reliability, prevalence, and implications for anti\u2010amyloid therapy"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3577-5174","authenticated-orcid":false,"given":"Ernest","family":"Priv\u0161ek","sequence":"first","affiliation":[{"name":"Division of Clinical Geriatrics Center for Alzheimer Research Department of Neurobiology, Care Sciences and Society Karolinska Institutet  Huddinge Sweden"},{"name":"Department of Radiology Institute of Oncology Ljubljana  Ljubljana Slovenia"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Marseglia","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics Center for Alzheimer Research Department of Neurobiology, Care Sciences and Society Karolinska Institutet  Huddinge Sweden"},{"name":"Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Ko\u0161uti\u0107","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Interventional Radiology Slovenj Gradec General Hospital  Slovenj Gradec Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rosenberg","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics Center for Alzheimer Research Department of Neurobiology, Care Sciences and Society Karolinska Institutet  Huddinge Sweden"},{"name":"Department of Public Health, Lifestyles and Living Environments Finnish Institute for Health and Welfare  Helsinki Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Granberg","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology Karolinska University Hospital  Stockholm Sweden"},{"name":"Department of Clinical Neuroscience Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milica G.","family":"Kramberger","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics Center for Alzheimer Research Department of Neurobiology, Care Sciences and Society Karolinska Institutet  Huddinge Sweden"},{"name":"Faculty of Medicine University of Ljubljana  Ljubljana Slovenia"},{"name":"Department of Neurology University Medical Centre  Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miia","family":"Kivipelto","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics Center for Alzheimer Research Department of Neurobiology, Care Sciences and Society Karolinska Institutet  Huddinge Sweden"},{"name":"Ageing Epidemiology Research Unit School of Public Health Imperial College London  London UK"},{"name":"Theme Inflammation and Aging Karolinska University Hospital  Huddinge Sweden"},{"name":"Institute of Public Health and Clinical Nutrition University of Eastern Finland  Kuopio Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Westman","sequence":"additional","affiliation":[{"name":"Division of Clinical Geriatrics Center for Alzheimer Research Department of Neurobiology, Care Sciences and Society Karolinska Institutet  Huddinge Sweden"},{"name":"Ageing Epidemiology Research Unit School of Public Health Imperial College London  London UK"},{"name":"Theme Inflammation and Aging Karolinska University Hospital  Huddinge Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,30]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(23)00131\u2010X"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.044167"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(22)00208\u20103"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.30"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100150"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.526996"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c34a7d"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/imj.16614"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.599837"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102478"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4248"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000210535.20297.ae"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000201043"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100476"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc25\u2010S002"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010026\u201001972\u20102"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15606141"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fninf.2023.1204186"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2018.08.002"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2016.2528129"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547\u2010022\u201001530\u20104"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701\u2010024\u201006267\u20109"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2024.103415"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010021\u201093427\u2010x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","DOI":"10.1148\/ryai.2021210013","article-title":"Integrating Al algorithms into the clinical workflow","volume":"3","author":"Juluru K","year":"2021","journal-title":"Radiol Artif Intell"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2023.01.002"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.543866"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2013.00057"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.115.016261"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2016.0292"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000194266.55694.1e"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.595181"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.39571"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001441\u20108"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70375"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70472","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dad2.70472","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70472","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:10:10Z","timestamp":1790824210000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.70472"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,30]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/dad2.70472"],"URL":"https:\/\/doi.org\/10.1002\/dad2.70472","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,30]]},"assertion":[{"value":"2026-05-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70472"}}