{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:40:19Z","timestamp":1792554019899,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T00:00:00Z","timestamp":1792454400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Amyloid\u2010related imaging abnormalities (ARIA) are a major safety concern in anti\u2010amyloid therapy for Alzheimer's disease (AD), but real\u2010world data remain limited. We investigated risk factors, temporal characteristics, and spatial distribution of ARIA in aducanumab\u2010treated patients and assessed the safety of apolipoprotein E (\n                      <jats:italic>APOE)<\/jats:italic>\n                      genotype\u2013tailored dosing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      We retrospectively analyzed 168 patients with a Clinical Dementia Rating (CDR) of 0.5 to 2 treated with aducanumab between 2022 and 2024. Dosing was individualized by\n                      <jats:italic>APOE<\/jats:italic>\n                      genotype. Serial magnetic resonance imaging (MRI) detected ARIA, multivariable regression identified risk factors, and ARIA with edema or effusion (ARIA\u2010E) lesions were manually segmented to generate topographical maps.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 164 patients, 33 (20.1%) developed ARIA\u2010E, with incidence increasing by\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 status (12.5% non\u2010carriers, 19.5% heterozygotes, 50.0% homozygotes;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.002). Lesions showed posterior predominance. Independent risk factors included\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 homozygosity, CDR 2, and hypertension. Most cases did not require treatment discontinuation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>ARIA\u2010E risk during aducanumab therapy was influenced by genetic and clinical factors, supporting genotype\u2010tailored titration in practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70473","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T03:03:30Z","timestamp":1792551810000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Topography and risk factors of amyloid\u2010related imaging abnormality: real\u2010world data from 168 aducanumab\u2010treated patients at a private clinic in South Korea"],"prefix":"10.1002","volume":"18","author":[{"given":"Soyeon","family":"Yoon","sequence":"first","affiliation":[{"name":"Alzheimer's Disease Convergence Research Center Samsung Medical Center  Seoul Republic of Korea"},{"name":"Department of Neurology Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jehyun","family":"Ahn","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Convergence Research Center Samsung Medical Center  Seoul Republic of Korea"},{"name":"Department of Neurology Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seongmi","family":"Kim","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Convergence Research Center Samsung Medical Center  Seoul Republic of Korea"},{"name":"Department of Neurology Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoungmin","family":"Kim","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Convergence Research Center Samsung Medical Center  Seoul Republic of Korea"},{"name":"Department of Neurology Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Happymind Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo Kyung","family":"An","sequence":"additional","affiliation":[{"name":"Happymind Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Gyu","family":"Na","sequence":"additional","affiliation":[{"name":"Human Medical Imaging and Intervention Center  Seoul Republic of Korea"},{"name":"Department of Radiology Gangneung Asan Hospital University of Ulsan College of Medicine  Gangneung Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Ju","family":"Kim","sequence":"additional","affiliation":[{"name":"Beaubrain Healthcare Inc.  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kichang","family":"Kwak","sequence":"additional","affiliation":[{"name":"Beaubrain Healthcare Inc.  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Won","family":"Seo","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Convergence Research Center Samsung Medical Center  Seoul Republic of Korea"},{"name":"Department of Neurology Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"},{"name":"Beaubrain Healthcare Inc.  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0098-7592","authenticated-orcid":false,"given":"Duk L.","family":"Na","sequence":"additional","affiliation":[{"name":"Alzheimer's Disease Convergence Research Center Samsung Medical Center  Seoul Republic of Korea"},{"name":"Department of Neurology Samsung Medical Center, Sungkyunkwan University School of Medicine  Seoul Republic of Korea"},{"name":"Happymind Clinic  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,20]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"PrinceM WimoA GuerchetM AliG\u2010C WuY\u2010T PrinaM.International AsD ed.World Alzheimer Report 2015.2015."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature19323"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.16049"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/trc2.70055"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2024.12.002"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.5205"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2024.1326784"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2351"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(12)70015\u20107"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102014\u2010309493"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010160122"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181c67808"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.469"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001441\u20108"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.12101"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010160216"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.4161"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.70062"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2025.0065"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2212948"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.13239"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12748"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(07)70178\u20103"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182815485"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.34"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.7.1071"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.12779\/dnd.2023.22.1.1"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13755"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2022.30"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae211"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26511"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.862369"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.233381"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP272450"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100031\u20101277990"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1136\/practneurol\u20102021\u2010003194"}],"container-title":["Alzheimer's &amp; 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