{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:51:09Z","timestamp":1791395469476,"version":"4.3.3"},"reference-count":38,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":69,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Amyloid burden may relate to semantic fluency through tau and astrocytic pathways, but their contributions remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>In this cross\u2010sectional study, we analyzed 210 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with amyloid positron emission tomography (PET), tau PET, plasma glial fibrillary acidic protein (GFAP), and animal fluency. Joint mediation models estimated indirect effects through language\u2010network tau and GFAP, with subgroup analyses in amyloid beta (A\u03b2)\u2010positive participants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      In the full sample, both tau and GFAP significantly mediated the association between amyloid burden and animal fluency, with a larger, more robust estimate for tau. Direct effects were non\u2010significant. Among A\u03b2\u2010positive participants, tau mediation remained significant, whereas GFAP mediation was attenuated. The dual\u2010mediator model showed a significant combined indirect effect (average causal mediation effects [ACME]\u00a0=\u00a0\u22120.211). Exploratory analyses suggested possible apolipoprotein E\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 moderation of the tau\u2010mediated pathway.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Amyloid\u2010related semantic fluency impairment was associated with language\u2010network tau and astrocytic reactivity, with tau the stronger mediator, supporting biomarker\u2010defined heterogeneity in language vulnerability across the Alzheimer's continuum.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70475","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T06:50:17Z","timestamp":1788936617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma GFAP and language\u2010network tau mediate the effect of amyloid burden on semantic fluency: A mediation analysis"],"prefix":"10.1002","volume":"18","author":[{"given":"Wei","family":"Han","sequence":"first","affiliation":[{"name":"Department of Evidence\u2010Based Medicine Xuanwu Hospital Capital Medical University  Beijing China"},{"name":"Beijing Municipal Geriatric Medical Research Center Beijing Geriatric Healthcare Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Yihua Biotechnology Co., Ltd  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peishen","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing Yihua Biotechnology Co., Ltd  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhao","family":"An","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Sanbo Brain Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinye","family":"Han","sequence":"additional","affiliation":[{"name":"Beijing Yihua Biotechnology Co., Ltd  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1887-1931","authenticated-orcid":false,"given":"Yihua","family":"An","sequence":"additional","affiliation":[{"name":"Beijing Yihua Biotechnology Co., Ltd  Beijing China"},{"name":"Department of Neurosurgery Sanbo Brain Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging 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