{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:51:09Z","timestamp":1791395469434,"version":"4.3.3"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":76,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Frontotemporal lobar degeneration (FTLD) often affects younger patients, making time to diagnosis especially consequential. Most evidence comes from high\u2010income countries, with limited data from Latin America.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We studied 415 individuals with FTLD\u2010associated syndromes from 12 sites in six Latin American countries in the Multi\u2010Partner Consortium to Expand Dementia Research in Latin America (ReDLat) cohort. Time to diagnosis was calculated using clinician\u2010reported symptom onset (T\u2010Reported) and criteria\u2010based onset (T\u2010Criteria). Associations with phenotype, social determinants of health, education, age at onset, sex, symptom presentation, and genetic status were examined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Mean time to diagnosis was 3.33 years using T\u2010Reported and 2.97 years using T\u2010Criteria. Times were longest in behavioral variant frontotemporal dementia and primary progressive aphasia variants. Younger age at onset was associated with longer time to diagnosis. Genetic carriers showed earlier onset but similar time to diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Time to diagnosis remains substantial, particularly in younger patients and canonical frontotemporal dementia phenotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:list list-type=\"bullet\">\n                        <jats:list-item>\n                          <jats:p>Mean time to diagnosis remains high across frontotemporal lobar degeneration (FTLD) syndromes.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Diagnostic delay in FTLD in Latin America averages \u22483 years.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Younger onset is linked to longer time to diagnosis.<\/jats:p>\n                        <\/jats:list-item>\n                        <jats:list-item>\n                          <jats:p>Canonical frontotemporal dementia phenotypes show the longest diagnostic delays.<\/jats:p>\n                        <\/jats:list-item>\n                      <\/jats:list>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70476","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:26:50Z","timestamp":1789468010000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Time to diagnosis in FTLD\u2010associated syndromes in Latin America"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7420-8547","authenticated-orcid":false,"given":"Nahuel","family":"Magrath\u2010Guimet","sequence":"first","affiliation":[{"name":"Department of Cognitive Neurology Neuropsychiatry and Neuropsychology Fleni  Buenos Aires Argentina"},{"name":"Atlantic Fellow for Equity in Brain Health at the Global Brain Health Institute (GBHI) University of California San Francisco (UCSF)  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florentina","family":"Morello\u2010Garcia","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences (INEU) Fleni\u2010CONICET  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loana","family":"De Los Santos","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neurology Neuropsychiatry and Neuropsychology Fleni  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Ardohain\u2010Cristalli","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neurology Neuropsychiatry and Neuropsychology Fleni  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Tabernero","sequence":"additional","affiliation":[{"name":"Cognitive Neurology Center Buenos Aires British Hospital \u2010 CONICET Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hern\u00e1n","family":"Chaves","sequence":"additional","affiliation":[{"name":"Institute of Neurosciences (INEU) Fleni\u2010CONICET  Buenos Aires Argentina"},{"name":"Department of Diagnostic Imaging Fleni  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Bagnati","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neurology Neuropsychiatry and Neuropsychology Fleni  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Francisco","family":"Allegri","sequence":"additional","affiliation":[{"name":"Department of Cognitive Neurology Neuropsychiatry and Neuropsychology Fleni  Buenos Aires Argentina"},{"name":"Department of Neurosciences Universidad de la Costa (CUC)  Barranquilla Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Migeot","sequence":"additional","affiliation":[{"name":"Latin American Brain Health Institute (BrainLat) Universidad Adolfo Iba\u00f1ez  Santiago Chile"},{"name":"Global Brain Health Institute (GBHI) Trinity College Dublin  Dublin, Dublin Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana","family":"Acosta\u2010Uribe","sequence":"additional","affiliation":[{"name":"Grupo de Neurociencias de Antioquia (GNA) Facultad de Medicina Universidad de Antioquia  Medell\u00edn 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