{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:51:07Z","timestamp":1791395467801,"version":"4.3.3"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:00:00Z","timestamp":1789344000000},"content-version":"vor","delay-in-days":75,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005294","name":"Massachusetts General Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005294","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011699","name":"Siemens Healthineers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011699","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Anti\u2010amyloid therapies such as lecanemab require magnetic resonance imaging (MRI) screening to exclude patients with\u00a0&gt;\u00a04 gradient\u2010recalled echo (GRE)\u2010detected microhemorrhages or any superficial siderosis (SS). Although GRE and susceptibility\u2010weighted imaging (SWI) are both accepted, they differ in detection performance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We retrospectively analyzed 224 eligibility MRIs with paired GRE and SWI from a single academic health system. Six neuroradiologists assessed a 20\u2010scan reliability subset; the remaining 204 scans were assigned to one rater for hemorrhagic lesion detection and MRI\u2010based eligibility classification. Interobserver reliability was calculated using intraclass correlation coefficients (ICCs), and sequence differences were evaluated using non\u2010parametric tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      SWI detected more microhemorrhages than GRE (mean 1.24\u00a0vs. 0.67,\n                      <jats:italic>p\u00a0&lt;<\/jats:italic>\n                      \u00a00.0001), identified eight additional SS cases, and showed higher interobserver agreement (ICC 0.951\u00a0vs. 0.764,\n                      <jats:italic>p\u00a0&lt;<\/jats:italic>\n                      \u00a00.01). SWI classified more patients as MRI ineligible than GRE (26\/204 [12.7%] vs. 11\/204 [5.4%]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>SWI identifies more exclusionary hemorrhagic findings and demonstrates greater reproducibility than GRE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70477","type":"journal-article","created":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T05:17:08Z","timestamp":1789449428000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Imaging for anti\u2010amyloid therapy eligibility: Comparing GRE and SWI in detecting microhemorrhages and superficial siderosis"],"prefix":"10.1002","volume":"18","author":[{"given":"Jeremy N.","family":"Ford","sequence":"first","affiliation":[{"name":"Department of Radiology Mass General Brigham and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5687-4186","authenticated-orcid":false,"given":"Suely Fazio","family":"Ferraciolli","sequence":"additional","affiliation":[{"name":"Department of Radiology Mass General Brigham and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Odette Ganem","family":"Chagui","sequence":"additional","affiliation":[{"name":"Department of Radiology Mass General Brigham and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin Relerford","family":"III","sequence":"additional","affiliation":[{"name":"Department of Radiology Mass General Brigham and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esteban Calle","family":"Cadavid","sequence":"additional","affiliation":[{"name":"Department of Radiology Mass General Brigham and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Dickson","sequence":"additional","affiliation":[{"name":"Department of Neurology Mass General Brigham and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Vejdani\u2010Jahromi","sequence":"additional","affiliation":[{"name":"Tufts University School of Medicine  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew N.","family":"DeSalvo","sequence":"additional","affiliation":[{"name":"Department of Radiology Mass General Brigham and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana A. Ramirez","family":"Gomez","sequence":"additional","affiliation":[{"name":"Department of Neurology Mass General Brigham and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonghwan","family":"Yee","sequence":"additional","affiliation":[{"name":"Department of Radiology Mass General Brigham and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry R.","family":"Griffin","sequence":"additional","affiliation":[{"name":"Department of Radiology Mass General Brigham and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Kozak","sequence":"additional","affiliation":[{"name":"Department of Radiology Mass General Brigham and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saurabh","family":"Rohatgi","sequence":"additional","affiliation":[{"name":"Department of Radiology Mass General Brigham and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond Y.","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Radiology Mass General Brigham and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Gomez\u2010Isla","sequence":"additional","affiliation":[{"name":"Department of Neurology Mass General Brigham and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Radiology Mass General Brigham and Harvard Medical School  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3500"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.14283\/jpad.2023.30"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43933-5"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-230164"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A1355"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00062\u2010012\u20100185\u20107"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.599837"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100220"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2025.0324"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurol.2023.10.008"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4525"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/1971400917690166"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.113.002267"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1971400916665376"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A0748"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00234\u2010018\u20102055\u20108"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A4082"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A6295"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/str.46.suppl_1.wmp119"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.05.2351"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.55800"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010024\u201001669\u20104"}],"container-title":["Alzheimer's &amp; 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