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In\n                      <jats:italic>APOE<\/jats:italic>\n                      \u025b4 carriers only, higher depression severity and lower sleep efficiency were associated with greater total A\u03b2 burden and indicated greater likelihood of reaching clinical cutoffs for amyloid positivity. The effects of depressive symptoms and sleep efficiency were statistically unique and additive. Exploratory analyses demonstrated\n                      <jats:italic>APOE<\/jats:italic>\n                      \u025b4 also moderated the effect of lifetime duration of untreated depression on increased A\u03b2.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>\n                      Depression severity and sleep efficiency's relationship with A\u03b2 may be dependent on the presence of the\n                      <jats:italic>APOE<\/jats:italic>\n                      \u025b4 allele. This, among other individual differences, may partially explain mixed findings examining LLD as a risk factor for Alzheimer's disease. Furthermore, these findings do not suggest that the relationship between depression severity and amyloid is explained by the confounding role of sleep duration or sleep efficiency.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70478","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T07:35:41Z","timestamp":1791531341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Depression severity and sleep efficiency's associations with amyloid burden are additive but dependent on underlying genetic risk in late life depression"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6808-6811","authenticated-orcid":false,"given":"Anita","family":"Shankar","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California, San Francisco  San Francisco California USA"},{"name":"San Francisco VA Health Care System San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Kryza\u2010Lacombe","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California, San Francisco  San Francisco California USA"},{"name":"San Francisco VA Health Care System San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip S.","family":"Insel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Harris","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California, San Francisco  San Francisco California USA"},{"name":"San Francisco VA Health Care System San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle T.","family":"Kassel","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California, San Francisco  San Francisco California USA"},{"name":"San Francisco VA Health Care System San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizabeth","family":"Goldstein","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California, San Francisco  San Francisco California USA"},{"name":"San Francisco VA Health Care System San Francisco California USA"},{"name":"The Center for Data to Discovery and Delivery Innovation (3DI) San Francisco VA Health Care System San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Krystal","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Landau","sequence":"additional","affiliation":[{"name":"Neuroscience Department Helen Wills Neuroscience Institute University of California Berkeley  Berkeley California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duygu","family":"Tosun","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging University of California, San Francisco  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meryl A.","family":"Butters","sequence":"additional","affiliation":[{"name":"Department of Psychiatry School of Medicine University of Pittsburgh  Pittsburgh Pennsylvania 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