{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:51:03Z","timestamp":1791395463459,"version":"4.3.3"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":78,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Blood biomarkers like phosphorylated tau (p\u2010tau)217 offer high diagnostic accuracy for Alzheimer's disease (AD) but face implementation challenges in low\u2010prevalence settings. We evaluated the Altoida NeuroMarker Platform as a digital cognitive triage tool before plasma p\u2010tau217 testing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>XGBoost models were trained to predict mild cognitive impairment (MCI) and p\u2010tau217 status in 688 individuals across Australia, Spain, and the United States using the Altoida NeuroMarker. p\u2010tau217 status was dichotomized using a threshold of 0.04 pg\/mL (LucentAD). We modeled a two\u2010step workflow (Altoida, plasma p\u2010tau217) to enrich downstream biomarker testing, assuming 30% prevalence of AD pathology.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>\n                      The Altoida NeuroMarker accurately identified MCI (receiver operating characteristic area under the curve [ROC AUC]\u00a0=\u00a00.89\u00a0\u00b1\u00a00.01) and p\u2010tau217 elevation (ROC AUC\u00a0=\u00a00.77\u00a0\u00b1\u00a00.08). Predicted MCI was significantly associated with elevated pTau217 (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a00.004). When used upstream, the Altoida NeuroMarker ruled out 64.4% of participants (negative predictive value 90.2%), shifting the pre\u2010test probability of AD pathology to 66.6%, and improving the modeled positive predictive value of plasma p\u2010tau217 from 81.7% to 95.3%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>This workflow outlines a scalable path to enrich blood\u2010based biomarker testing after digital cognitive screening.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70486","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T11:01:02Z","timestamp":1789642862000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A scalable workflow using digital cognitive assessment and pTau217 for MCI detection"],"prefix":"10.1002","volume":"18","author":[{"given":"Srinivasan","family":"Vairavan","sequence":"first","affiliation":[{"name":"Johnson &amp; Johnson  Titusville New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Griffin","sequence":"additional","affiliation":[{"name":"Altoida Inc.  Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wilson","sequence":"additional","affiliation":[{"name":"Quanterix  Billerica Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gallen","family":"Triana\u2010Baltzer","sequence":"additional","affiliation":[{"name":"Johnson &amp; Johnson  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Brugada\u2010Ramentol","sequence":"additional","affiliation":[{"name":"Altoida Inc.  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Washington District of Columbia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy","family":"Mackintosh","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsey","family":"Mette","sequence":"additional","affiliation":[{"name":"Quanterix  Billerica Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James D.","family":"Doecke","sequence":"additional","affiliation":[{"name":"Australian E\u2010Health Research Centre Health &amp; Biosecurity CSIRO  Brisbane Australia"},{"name":"Centre for Precision Health Edith Cowan University  Joondalup Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Robertson","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry","family":"Ward","sequence":"additional","affiliation":[{"name":"The Florey Institute of Neuroscience and Mental Health The University of Melbourne  Parkville Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo S\u00e1nchez","family":"Benavides","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"Hospital del Mar Research Institute  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y Envejecimiento Saludable (CIBERFES) Instituto de Salud Carlos III  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Minguillon","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC) Pasqual Maragall Foundation  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Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona \u2013 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mircea","family":"Balasa","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red en Enfermedades Neurodegenerativas (CIBERNED)  Madrid Spain"},{"name":"Alzheimer's Disease and other Cognitive Disorders Unit Hospital Cl\u00ednic de Barcelona Fundaci\u00f3 de Recerca Cl\u00ednic Barcelona \u2013 Institut d'Investigacions Biom\u00e8diques August Pi i Sunyer (IDIBAPS) Universitat de Barcelona  Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oriol Grau","family":"Rivera","sequence":"additional","affiliation":[{"name":"Barcelona\u03b2eta Brain Research Center (BBRC) Pasqual Maragall Foundation  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Fragilidad y 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