{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:04:54Z","timestamp":1790784294285,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:00:00Z","timestamp":1790726400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz & Dem Diag Ass & Dis Mo"],"published-print":{"date-parts":[[2026,10]]},"abstract":"Abstract<\/jats:title>\n \n INTRODUCTION<\/jats:title>\n Real\u2010world prognostic evidence for cerebrospinal fluid (CSF) biomarkers during lecanemab therapy remains limited. We examined whether baseline CSF phosphorylated tau 181 (pTau181), total tau, and amyloid beta (A\u03b2) 42\/A\u03b240 were associated with 6\u2010month clinical change.<\/jats:p>\n <\/jats:sec>\n \n METHODS<\/jats:title>\n This prospective single\u2010center cohort included 50 patients with early Alzheimer's disease spectrum treated with lecanemab. CSF biomarkers were measured using the Lumipulse G system. The primary outcome was 6\u2010month change in Clinical Dementia Rating Sum of Boxes (CDR\u2010SB). Models were adjusted for age, sex, and baseline Mini\u2010Mental State Examination; sensitivity analyses included APOE \u03b54 status.<\/jats:p>\n <\/jats:sec>\n \n RESULTS<\/jats:title>\n \n CDR\u2010SB worsening occurred in 19 participants (38.0%). Higher pTau181 (\u03b2 per SD\u00a0=\u00a00.408; 95% CI: 0.106 to 0.709;\n p<\/jats:italic>\n \u00a0=\u00a00.0091) and total tau (\n \u03b2<\/jats:italic>\n \u00a0=\u00a00.341; 95% CI: 0.032 to 0.651;\n p<\/jats:italic>\n \u00a0=\u00a00.0314) were associated with worsening. A\u03b242\/A\u03b240 was not.\n <\/jats:p>\n <\/jats:sec>\n \n DISCUSSION<\/jats:title>\n Baseline CSF pTau181 and total tau were associated with 6\u2010month clinical trajectories, supporting cautious cohort\u2010level risk stratification.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/dad2.70487","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T15:15:29Z","timestamp":1790781329000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Baseline CSF tau and short\u2010term clinical change during lecanemab therapy: A prospective real\u2010world cohort study in Japan"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6243-7852","authenticated-orcid":false,"given":"Ryuichi","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Neurology Hyogo Prefectural Rehabilitation Hospital at Nishi\u2010Harima Tatsuno Hyogo Japan"},{"name":"Dementia\u2010Related Disease Medical Center Hyogo Prefectural Rehabilitation Hospital at Nishi\u2010Harima Tatsuno Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Kashibayashi","sequence":"additional","affiliation":[{"name":"Dementia\u2010Related Disease Medical Center Hyogo Prefectural Rehabilitation Hospital at Nishi\u2010Harima Tatsuno Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Fujita","sequence":"additional","affiliation":[{"name":"Dementia\u2010Related Disease Medical Center Hyogo Prefectural Rehabilitation Hospital at Nishi\u2010Harima Tatsuno Hyogo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohsuke","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Dementia\u2010Related Disease Medical Center Hyogo Prefectural Rehabilitation Hospital at Nishi\u2010Harima Tatsuno Hyogo Japan"},{"name":"Department of Public Health Kobe University Graduate School of Health Sciences Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Hashiramoto","sequence":"additional","affiliation":[{"name":"Department of Biophysics Kobe University Graduate School of Health Sciences Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisatomo","family":"Kowa","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Science Kobe University Graduate School of Health Sciences Kobe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Mizuta","sequence":"additional","affiliation":[{"name":"Department of Neurology Hyogo Prefectural Rehabilitation Hospital at Nishi\u2010Harima Tatsuno Hyogo 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optimal cut\u2010off values in receiver operating characteristic curve analysis: a review","volume":"77","author":"Tustumi F","year":"2022","journal-title":"Clinics (Sao Paulo)"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010025\u201001912\u20106"}],"container-title":["Alzheimer's & Dementia: Diagnosis, Assessment & Disease 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