{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:48:28Z","timestamp":1791978508312,"version":"4.4.0"},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>\n                      We assessed whether lifestyle, race\/ethnicity, and apolipoprotein E gene (\n                      <jats:italic>APOE<\/jats:italic>\n                      ) \u03b54 were associated with cognition or mood\/anxiety.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>\n                      This secondary cohort analysis used data from the Anti\u2010Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) Study and the Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) cohort. Cognitively unimpaired adults aged 65 to 85 years (\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a01705) reported baseline lifestyle behaviors (summed as healthy lifestyle index [HLI]).\n                      <jats:italic>APOE<\/jats:italic>\n                      \u03b54 carrier status and amyloid positron emission tomography were assessed at baseline, while cognitive, anxiety, and depressive outcomes were assessed longitudinally. Associations were tested using mixed\u2010effects models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Among Non\u2010Hispanic White participants, higher HLI was associated with fewer depressive symptoms, sufficient sleep was associated with smaller \u03b54\u2010related increases in anxiety, and excessive alcohol use amplified \u03b54\u2010related cognitive decline. Among participants from other racial\/ethnic groups, walking and higher HLI were associated with more favorable anxiety\/depression trajectories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Adequate sleep, limited alcohol, walking, and no smoking may support emotional and cognitive health.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70494","type":"journal-article","created":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:00:26Z","timestamp":1791975626000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Lifestyle,\n                    <i>APOE<\/i>\n                    \u03b54, amyloid burden, and race\/ethnicity differences in cognition, mood, and anxiety among cognitively unimpaired older adults"],"prefix":"10.1002","volume":"18","author":[{"given":"Shiwen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Public Health Sciences Thompson School of Social Work &amp; Public Health, University of Hawaii at Manoa  Honolulu Hawai\u02bbi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Health Policy Research University of California  Los Angeles California USA"},{"name":"Department of Epidemiology Fielding School of Public Health, University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Cunanan","sequence":"additional","affiliation":[{"name":"Department of Public Health Sciences Thompson School of Social Work &amp; Public Health, University of Hawaii at Manoa  Honolulu Hawai\u02bbi USA"},{"name":"Department of Research Kuakini Medical Center  Honolulu Hawai\u02bbi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal","family":"Masaki","sequence":"additional","affiliation":[{"name":"Department of Research Kuakini Medical Center  Honolulu Hawai\u02bbi USA"},{"name":"Department of Geriatric Medicine John A. Burns School of Medicine, University of Hawaii at Manoa  Honolulu Hawai\u02bbi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Webster","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine John A. Burns School of Medicine, University of Hawaii at Manoa  Honolulu Hawai\u02bbi USA"},{"name":"Pacific Health Research and Education Institute VA Pacific Islands Health Care System  Honolulu Hawai\u02bbi USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,14]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40120\u2010022\u201000338\u20108"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/s1041610203008664"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474\u20104422(21)00066\u20101"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010022\u201006068\u2010x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010170263"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20102667(21)00249\u20108"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010019\u20100333\u20105"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2012.263"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010132225"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjpad.2025.100367"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00295"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.14283\/jfa.2016.76"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2018.11.020"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010221167"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000855\u2010y"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010190538"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3007941"},{"key":"e_1_2_9_19_1","unstructured":"Anti\u2010Amyloid Treatment in Asymptomatic Alzheimer's (A4) Study and Longitudinal Evaluation of Amyloid Risk and Neurodegeneration (LEARN) Study. 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