{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:50:55Z","timestamp":1791395455219,"version":"4.3.3"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":85,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp;amp; Dem Diag Ass &amp;amp; Dis Mo"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Increasing clinical use of amyloid\u2010targeting treatments (ATTs) requires accessible biomarkers for Alzheimer's disease (AD). Although the utility of plasma phosphorylated tau 217 (p\u2010tau217) is well established in research cohorts and its use for identifying amyloid positivity among ATT candidates is expanding into clinical practice, real\u2010world evidence of its performance is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We evaluated the utility of LUMIPULSE plasma p\u2010tau217 in a real\u2010world cohort of 99 patients screened for ATT eligibility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Amyloid positivity was confirmed in 82 (82.8%) patients. Plasma p\u2010tau217 predicted amyloid status, with an area under the curve of 0.93. With a cutpoint (0.1795 pg\/mL) based on the Youden index, this approach achieved 95.1% sensitivity, 94.1% specificity, 98.7% positive predictive value, and 80.0% negative predictive value (NPV). Higher external thresholds led to a lower NPV, demonstrating that cut points must be optimized for clinical stages.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>These findings provide real\u2010world evidence supporting the clinical utility of p\u2010tau217 for ATT candidates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70497","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T09:15:17Z","timestamp":1790241317000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical utility of LUMIPULSE plasma p\u2010tau217 to identify amyloid positivity among candidates for amyloid\u2010targeting treatments in a real\u2010world cohort"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9314-7997","authenticated-orcid":false,"given":"Ryosuke","family":"Shimasaki","sequence":"first","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"},{"name":"Integrated Research Initiative for Living Well with Dementia Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"},{"name":"Department of Geriatric Medicine, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8281-0634","authenticated-orcid":false,"given":"Masanori","family":"Kurihara","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"},{"name":"Integrated Research Initiative for Living Well with Dementia Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Sato","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"},{"name":"Integrated Research Initiative for Living Well with Dementia Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"},{"name":"Dementia Inclusion and Therapeutics The University of Tokyo Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taro","family":"Bannai","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Hatano","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ishii","sequence":"additional","affiliation":[{"name":"Integrated Research Initiative for Living Well with Dementia Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"},{"name":"Research Team for Neuroimaging Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoko","family":"Ihara","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"},{"name":"Integrated Research Initiative for Living Well with Dementia Tokyo Metropolitan Institute for Geriatrics and Gerontology  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumito","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine, Graduate School of Medicine The University of Tokyo  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