{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:52:01Z","timestamp":1791298321920,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T00:00:00Z","timestamp":1791244800000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>Mounting evidence suggests overlapping pathology across Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease (PD), yet its extent and clinical implications remain unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>Cerebrospinal fluid\u00a0(CSF) amyloid beta (A\u03b2)42\/40, phosphorylated tau 181 (p\u2010tau181), neurofilament light chain (NfL), and total \u03b1\u2010synuclein were centrally measured using fully\u2010automated Elecsys immunoassays in 347 participants (European Platform for Neurodegenerative Diseases [EPND] cohort) and compared between groups. Associations of amyloid and tau positivity with cognitive and motor function were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Compared to controls, amyloid and tau levels were abnormal in DLB, but not in PD. Amyloid and tau positivity in DLB were associated with worse global cognitive outcomes, but not with motor performance. NfL levels were elevated across diseases, and total \u03b1\u2010synuclein levels were associated with tau positivity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>AD pathology is observed in DLB, and related to worse cognition, but it is less observed in PD. CSF NfL captures non\u2010disease\u2010specific processes, whereas CSF total \u03b1\u2010synuclein likely reflects CSF tau positivity. Results can help patient management in clinical practice and trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70498","type":"journal-article","created":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:27:37Z","timestamp":1791296857000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Amyloid, p\u2010tau, neurofilament light, and \u03b1\u2010synuclein cerebrospinal fluid biomarkers across Alzheimer's disease, dementia with Lewy bodies, and Parkinson's disease"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1980-5095","authenticated-orcid":false,"given":"Marianna","family":"Rizzo","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Neuropsychology, Alzheimer Centrum Limburg, Mental Health and Neuroscience Research Institute Maastricht University  Maastricht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte E.","family":"Teunissen","sequence":"additional","affiliation":[{"name":"Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam Neuroscience, Neurodegeneration Amsterdam UMC, Vrije Universiteit Amsterdam  Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  M\u00f6lndal Sweden"},{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"},{"name":"Department of Neurodegenerative Disease UCL Institute of Neurology  London UK"},{"name":"Wisconsin Alzheimer's Disease Research Center University of Wisconsin School of Medicine and Public Health  Madison Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[{"name":"Clinical Neurochemistry Laboratory Sahlgrenska University Hospital  M\u00f6lndal Sweden"},{"name":"Department of Psychiatry and Neurochemistry Institute of Neuroscience and Physiology the Sahlgrenska Academy at the University of Gothenburg  M\u00f6lndal Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendlyn","family":"Kollmorgen","sequence":"additional","affiliation":[{"name":"Roche Diagnostics GmbH  Penzberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rejko","family":"Kr\u00fcger","sequence":"additional","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine University of Luxembourg  Esch\u2010sur\u2010Alzette Luxembourg"},{"name":"Parkinson Research Clinic Centre Hospitalier de Luxembourg  Luxembourg Luxembourg"},{"name":"Luxembourg Institute of Health (LIH)  Strassen Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara B. G.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Luxembourg Centre for Systems Biomedicine University of Luxembourg  Esch\u2010sur\u2010Alzette Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dag","family":"Aarsland","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"},{"name":"Centre for Age\u2010Related Medicine Stavanger University Hospital, Stavanger  Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Borejko","sequence":"additional","affiliation":[{"name":"Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Hu","sequence":"additional","affiliation":[{"name":"Nuffield Department of Clinical Neurosciences University of Oxford  Oxford UK"},{"name":"Oxford Parkinson's Disease Centre University of Oxford  Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davit","family":"Chokoshvili","sequence":"additional","affiliation":[{"name":"Luxembourg National Data Service (LNDS)  Esch\u2010sur\u2010Alzette Luxembourg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jort E. G. B.","family":"Vijverberg","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC  Amsterdam Netherlands"},{"name":"Department of Epidemiology and Data Science Vrije Universiteit Amsterdam, Amsterdam UMC  Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afina W.","family":"Lemstra","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC  Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty M.","family":"Tijms","sequence":"additional","affiliation":[{"name":"Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC  Amsterdam Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabor C.","family":"Petzold","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn  Bonn Germany"},{"name":"Department of Vascular Neurology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Brockmann","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  T\u00fcbingen Germany"},{"name":"Hertie Institute for Clinical Brain Research Department of Neurodegenerative Diseases University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gasser","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  T\u00fcbingen Germany"},{"name":"Hertie Institute for Clinical Brain Research Department of Neurodegenerative Diseases University of T\u00fcbingen  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni B.","family":"Frisoni","sequence":"additional","affiliation":[{"name":"Memory Clinic Geneva University Hospitals  Geneva Switzerland"},{"name":"Laboratory of Neuroimaging of Aging University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"Hort","sequence":"additional","affiliation":[{"name":"Memory Clinic Department of Neurology 2nd Faculty of Medicine Charles University and Motol University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuzana","family":"Nedelska","sequence":"additional","affiliation":[{"name":"Memory Clinic Department of Neurology 2nd Faculty of Medicine Charles University and Motol University Hospital  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann\u2010Cecilie","family":"Hop\u00f8y","sequence":"additional","affiliation":[{"name":"Centre for Age\u2010Related Medicine Stavanger University Hospital, Stavanger  Stavanger Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tormod","family":"Fladby","sequence":"additional","affiliation":[{"name":"Department of Neurology Akershus University Hospital  L\u00f8renskog Norway"},{"name":"Institute of Clinical Medicine University of Oslo  Oslo Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Jessen","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn  Bonn Germany"},{"name":"Department of Psychiatry University of Cologne, Medical Faculty  Cologne Germany"},{"name":"Excellence Cluster on Cellular Stress Responses in Aging\u2010Associated Diseases (CECAD) University of Cologne  K\u00f6ln Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emrah","family":"D\u00fczel","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE)  Magdeburg Germany"},{"name":"Institute of Cognitive Neurology and Dementia Research (IKND) Otto\u2010von\u2010Guericke University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Spottke","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases (DZNE), Bonn  Bonn Germany"},{"name":"Department of Neurology University of Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter U.","family":"H\u00f6glinger","sequence":"additional","affiliation":[{"name":"Department of Neurology, LMU University Hospital Ludwig\u2010Maximilians\u2010Universit\u00e4t (LMU) M\u00fcnchen  Munich Germany"},{"name":"German Center for Neurodegenerative Diseases (DZNE)  Munich Germany"},{"name":"Munich Cluster for Systems Neurology (SyNergy)  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Mutel","sequence":"additional","affiliation":[{"name":"Memory Clinic Geneva University Hospitals  Geneva Switzerland"},{"name":"Laboratory of Neuroimaging of Aging University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Memory Clinic Geneva University Hospitals  Geneva Switzerland"},{"name":"Laboratory of Neuroimaging of Aging University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajaraman","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Sanofi \u2010 Rare and Neurologic Diseases Therapeutic Area  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter Jelle","family":"Visser","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology, Alzheimer Centrum Limburg, Mental Health and Neuroscience Research Institute Maastricht University  Maastricht Netherlands"},{"name":"Alzheimer Center Amsterdam Department of Neurology Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC  Amsterdam Netherlands"},{"name":"Department of Neurobiology, Care Sciences and Society, Division of Neurogeriatrics Karolinska Institutet  Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie J. B.","family":"Vos","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Neuropsychology, Alzheimer Centrum Limburg, Mental Health and Neuroscience Research Institute Maastricht University  Maastricht Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"EPND consortium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2022.102270"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3549"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp\u20102019\u2010321111"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010011\u20100852\u20109"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010008\u20100347\u20105"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010019\u20100333\u20105"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.01.010"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.09.009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.1031091"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010132306"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010021\u201000846\u2010z"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00326"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102019\u2010030379"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.2217\/nmt\u20102019\u20100016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010170231"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010017\u20100314\u20102"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010023\u201001168\u2010y"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2019.1632"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12897"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201054204\u2010z"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004058"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187889.17253.b1"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009323"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.4742"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.10459"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26498"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2019.04.078"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10121015"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD\u2010160322"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010021\u201000785\u20103"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12814"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.3746"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117229"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2015.3037"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2014.10.026"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.4172\/2161\u20100460.1000444"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/WAD.0000000000000381"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.2217\/BMM.14.105"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531\u2010022\u201000357\u20100"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010023\u201001379\u2010z"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2018.05.005"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2020.03.012"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2013.10.004"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1177271920950319"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471\u20104159.2012.07749.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2008.06.004"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awae203"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2024.107255"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26668"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200048"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195\u2010019\u20100537\u20105"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70144"}],"container-title":["Alzheimer's &amp; Dementia: Diagnosis, Assessment &amp; Disease Monitoring"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70498","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dad2.70498","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dad2.70498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:27:40Z","timestamp":1791296860000},"score":1,"resource":{"primary":{"URL":"https:\/\/alz-journals.onlinelibrary.wiley.com\/doi\/10.1002\/dad2.70498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1002\/dad2.70498"],"URL":"https:\/\/doi.org\/10.1002\/dad2.70498","archive":["Portico"],"relation":{},"ISSN":["2352-8729","2352-8729"],"issn-type":[{"value":"2352-8729","type":"print"},{"value":"2352-8729","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"2026-03-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70498"}}