{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T09:41:45Z","timestamp":1792230105629,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T00:00:00Z","timestamp":1792195200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["BCA527734"],"award-info":[{"award-number":["BCA527734"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["alz-journals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Alz &amp; Dem Diag Ass &amp; Dis Mo"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>INTRODUCTION<\/jats:title>\n                    <jats:p>It is unclear whether cerebrovascular and white matter changes contribute to mild behavioral impairment (MBI). White matter hyperintensities (WMHs) represent a prominent pathology for research due to association with cognitive decline. We investigated associations between MBI measures and WMH volume and spatial distribution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>METHODS<\/jats:title>\n                    <jats:p>We analyzed 1273 individuals with normal cognition or mild cognitive impairment. General linear models and voxel\u2010wise analyses were employed to examine WMHs in terms of volume and spatial distribution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>RESULTS<\/jats:title>\n                    <jats:p>Greater WMH volume was associated with higher MBI total score and MBI status in participants with normal cognition and mild cognitive impairment. Voxel\u2010wise analysis revealed a significant cluster in the left inferior longitudinal fasciculus associated with higher MBI total score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCUSSION<\/jats:title>\n                    <jats:p>Our findings suggest a contribution of WMH volume and spatial distribution to persistent later\u2010life behavioral symptoms. WMHs, especially in the left inferior longitudinal fasciculus, may serve as a neuroimaging marker of behavioral symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dad2.70500","type":"journal-article","created":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T08:55:11Z","timestamp":1792227311000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations of mild behavioral impairment and white matter hyperintensity patterns"],"prefix":"10.1002","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9223-9239","authenticated-orcid":false,"given":"Zdenek","family":"Linha","sequence":"first","affiliation":[{"name":"Department of Public Health Second Faculty of Medicine Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Dolezal","sequence":"additional","affiliation":[{"name":"Department of Public Health Second Faculty of Medicine Charles University  Prague Czech Republic"},{"name":"Department of Clinical Subspecialities Faculty of Health Studies University of Pardubice  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matej","family":"Seifert","sequence":"additional","affiliation":[{"name":"Department of Public Health Second Faculty of Medicine Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tejasvi","family":"Ravi","sequence":"additional","affiliation":[{"name":"Department of Public Health Second Faculty of Medicine Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahinoor","family":"Ismail","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry Clinical Neurosciences, Community Health Sciences, and Pathology &amp; Laboratory Medicine Hotchkiss Brain Institute University of Calgary  Calgary Canada"},{"name":"NIHR Exeter Biomedical Research Centre University of Exeter  Exeter UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavla Brennan","family":"Kearns","sequence":"additional","affiliation":[{"name":"Department of Public Health Second Faculty of Medicine Charles University  Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2015.05.017"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010160979"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyg.2025.1586418"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12007"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2024.136"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010021\u201001675\u20102"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010170632"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jagp.2013.01.006"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/circimaging.120.010460"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1474\u20104422(19)30079\u20101"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2022.882922"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccb.2022.100041"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2018.04.007"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c3666"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25084323"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf156"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398\u2010021\u201001206\u2010z"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.643271"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/08919887211016068"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024\u2010023\u201000631\u20106"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1177\/08919887251366634"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/dad2.70119"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.3233\/jad\u2010200011"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccb.2021.100028"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.advms.2022.06.002"},{"key":"e_1_2_9_27_1","unstructured":"Alzheimer's Disease Neuroimaging Initiative.ADNI [Internet]. c2026 [cited 2026May28]. 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