{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T10:21:21Z","timestamp":1792146081774,"version":"4.4.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2002,1,25]],"date-time":"2002-01-25T00:00:00Z","timestamp":1011916800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2002,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a case of fibrolamellar hepatocellular carcinoma (FL\u2010HCC) that metastasized to the posterior mediastinum. The diagnosis was made on fine\u2010needle aspiration biopsy (FNAB). The cytologic features were characterized by the presence of large, dishesive, polygonal cells with granular cytoplasm and well\u2010defined cell outlines resembling oncocytes. Groups of neoplastic hepatocytes containing bile pigment were also noted. The diagnosis of FL\u2010HCC in a metastatic site can pose diagnostic challenges on FNAB. The cytologic features overlap with a variety of tumors that have oncocytic features and also with melanoma and paraganglioma. Recognition of specific cytologic features of FL\u2010HCC can facilitate accurate diagnosis in a metastatic site. The cytologic findings and differential diagnoses of FL\u2010HCC that metastasized to the posterior mediastinum are discussed. Diagn. Cytopathol. 2002;26:95\u201398; DOI 10.1002\/dc.10047 \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.10047","type":"journal-article","created":{"date-parts":[[2004,10,27]],"date-time":"2004-10-27T14:12:00Z","timestamp":1098886320000},"page":"95-98","source":"Crossref","is-referenced-by-count":13,"title":["Fine\u2010needle aspiration cytology and differential diagnoses of fibrolamellar hepatocellular carcinoma metastatic to the mediastinum: Case report"],"prefix":"10.1002","volume":"26","author":[{"given":"Venetia R.","family":"Sarode","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudy","family":"Castellani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Post","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2002,1,25]]},"reference":[{"key":"e_1_2_1_2_2","series-title":"Diagnostic surgical pathology","first-page":"1589","author":"Saul SH","year":"1999"},{"key":"e_1_2_1_3_2","first-page":"867","article-title":"Fine needle aspiration cytology of fibrolamellar hepatocellular carcinoma","volume":"29","author":"Suen KC","year":"1985","journal-title":"Acta Cytol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840060410"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199909)21:3<180::AID-DC7>3.0.CO;2-O"},{"key":"e_1_2_1_6_2","first-page":"699","article-title":"Diagnosis of mediastinal lesions by fine needle aspiration","volume":"33","author":"Oostingh PE","year":"1989","journal-title":"Acta Cytol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(200001)22:1<16::AID-DC5>3.0.CO;2-T"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199907)21:1<51::AID-DC14>3.0.CO;2-Y"},{"key":"e_1_2_1_9_2","first-page":"999","volume-title":"The art and science of cytopathology","author":"De May RM","year":"1996"},{"key":"e_1_2_1_10_2","first-page":"386","article-title":"Fine needle aspiration cytology of paraganglionic tumors","volume":"32","author":"Gonzalez\u2010Campora R","year":"1988","journal-title":"Acta Cytol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000330978"},{"key":"e_1_2_1_12_2","first-page":"1124","volume-title":"The art and science of cytopathology","author":"De May RM","year":"1996"},{"key":"e_1_2_1_13_2","first-page":"942","volume-title":"Primitive neuroectodermal tumors and related lesions; soft tissue tumors","author":"Enzinger FM","year":"1999"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199909)21:3<194::AID-DC9>3.0.CO;2-B"},{"key":"e_1_2_1_15_2","first-page":"259","article-title":"The cytology of ganglioneuroma on fine needle aspiration cytology smears","volume":"26","author":"Polambi L","year":"1982","journal-title":"Acta Cytol"},{"key":"e_1_2_1_16_2","first-page":"520","volume-title":"Gut course: and where is the primary? 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