{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T16:05:05Z","timestamp":1760976305722},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,2,27]],"date-time":"2002-02-27T00:00:00Z","timestamp":1014768000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2002,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 52\u2010year\u2010old previously healthy Caucasian woman presented with superior vena cava syndrome, secondary to compression of a bulky anterior mediastinal mass involving the right lung. Fine\u2010needle aspiration biopsy of the mediastinum yielded large epithelioid cells intermingled with small mature lymphocytes. The epithelioid cells are LCA positive, expressing cytoplasmic CD3 diffusely and TIA\u20101 focally, but negative for EMA, CD4, CD8, CD15, CD20, CD30, and CD56. The TIA\u20101+ cytoplasmic granules correlated to the azurophilic granules in Diff\u2010Quik\u2010stained cells, pink granules in Ultrafast Papanicolaou\u2010stained cells, and dense core granules in electron microscopy. In situ hybridization for Epstein\u2010Barr viral RNA was negative. The background small lymphocytes were composed of a majority of CD4+ T\u2010lymphocytes and minority of CD8+ T\u2010lymphocytes. The patient responded well to six cycles of CHOP chemotherapy, followed by radiation with a total dose of 4140 cGy delivered to the mediastinum in 23 fractions. On the chest X\u2010ray taken 6 mo later, there was minimal apical fibrosis with no evidence of an acute intrathoracic pathology. To the best of our knowledge, this case may be the first report of cytotoxic large T\u2010cell lymphoma of the mediastinum. Diagn. Cytopathol. 2002;26:154\u2013157; DOI 10.1002\/dc.10050 \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.10050","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T23:09:26Z","timestamp":1030316966000},"page":"154-157","source":"Crossref","is-referenced-by-count":5,"title":["TIA\u20101+ cytotoxic large T\u2010cell lymphoma of the mediastinum: Case report"],"prefix":"10.1002","volume":"26","author":[{"given":"Grace C.H.","family":"Yang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herman T.","family":"Yee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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