{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:04:43Z","timestamp":1770822283047,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2002,8,28]],"date-time":"2002-08-28T00:00:00Z","timestamp":1030492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2002,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Increased rates of squamous intraepithelial lesion (SIL) diagnosis with liquid\u2010based cervicovaginal cytology (CVC) methods are well documented. This retrospective study compares the ability of the ThinPrep\u2122 Pap Test (TP) and the conventional Pap smear (CP) to detect biopsy\u2010proven SIL and to exclude nonneoplastic disease. All CVC reports from January 1999 through December 2000 from seven community Family Medicine clinics affiliated with the University of Nebraska were reviewed. For women with at least one CVC diagnosis of epithelial cell abnormality (ECA), follow\u2010up histology, cytology, and clinical data were obtained. Statistical analysis was performed using the chi\u2010square method. SIL was diagnosed in 166 of 3,286 patients by TP (5.1%) and in 169 of 4,872 patients by CP (3.5%) (<jats:italic>P<\/jats:italic> &lt; 0.001); 32 of the TP diagnoses (1.0%) and 34 of the CP diagnoses (0.7%) were high\u2010grade SIL (HSIL). Atypical squamous or glandular cells of undetermined significance (ASCUS\/AGUS) was the most severe abnormality diagnosed by TP in 218 patients (6.6%) and by CP in 279 patients (5.7%). Follow\u2010up histology data on CVC SIL diagnoses showed evidence of cervical intraepithelial neoplasia in 94 patients screened by TP (2.9%) and in 79 patients screened by CP (1.6%) (<jats:italic>P<\/jats:italic> &lt; 0.001); the biopsy diagnoses were CIN 2 or CIN 3 in 34 patients in the TP group (1.0%) and in 28 patients in the CP group (0.6%) (<jats:italic>P<\/jats:italic> &lt; 0.025). Follow\u2010up of patients in whom the first ECA CVC diagnosis was ASCUS or AGUS disclosed a positive predictive value for CIN of 22.8% for TP ASCUS\/AGUS diagnoses and 11.9% for CP ASCUS\/AGUS diagnoses (<jats:italic>P<\/jats:italic> &lt; 0.005). In this population, TP was significantly better than CP in detecting biopsy\u2010 proven disease and in screening out benign abnormalities. Diagn. Cytopathol. 2002;27:185\u2013188. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.10158","type":"journal-article","created":{"date-parts":[[2002,9,5]],"date-time":"2002-09-05T20:44:35Z","timestamp":1031258675000},"page":"185-188","source":"Crossref","is-referenced-by-count":39,"title":["Conventional and liquid\u2010based cervicovaginal cytology: A comparison study with clinical and histologic follow\u2010up"],"prefix":"10.1002","volume":"27","author":[{"given":"John J.","family":"Baker","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,8,28]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19990425)87:2<48::AID-CNCR2>3.0.CO;2-D"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0029-7844(97)00228-7"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2000.1588"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1159\/000327859"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000333908"},{"key":"e_1_2_1_7_2","first-page":"500","article-title":"Comparison of fluid\u2010based, thin\u2010layer processing and conventional Papanicolaou methods for uterine cervical cytology","volume":"98","author":"Wang TY","year":"1999","journal-title":"J Formos Med 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smear method in the clinical setting of an independent laboratory and an outpatient screening population in New England","volume":"123","author":"Diaz\u2010Rosario LA","year":"1999","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199902)20:2<70::AID-DC5>3.0.CO;2-E"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000328292"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000331547"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(200001)22:1<52::AID-DC14>3.0.CO;2-#"},{"key":"e_1_2_1_18_2","first-page":"233","article-title":"Evaluation of the ThinPrep Papanicolaou test in clinical practice: 6\u2010month study of 16,541 cases with histological correlation in 220 cases","volume":"5","author":"Yeoh GPS","year":"1999","journal-title":"HKMJ"},{"key":"e_1_2_1_19_2","first-page":"353","article-title":"Direct\u2010to\u2010vial experience with AutoCyte PREP in a small New England regional cytology practice","volume":"46","author":"Marino JF","year":"2001","journal-title":"J Reprod Med"},{"key":"e_1_2_1_20_2","first-page":"912","article-title":"Preliminary assessment of the AutoCyte PREP: direct\u2010to\u2010vial performance","volume":"45","author":"Tench W","year":"2000","journal-title":"J Reprod Med"},{"key":"e_1_2_1_21_2","first-page":"11","article-title":"Biopsy\u2010based comparison of liquid\u2010based, thin\u2010layer preparations to conventional Pap smears","volume":"45","author":"Vassilakos P","year":"2000","journal-title":"J Reprod Med"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1159\/000331543"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5891"}],"container-title":["Diagnostic 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