{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:14:51Z","timestamp":1773868491977,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2002,9,30]],"date-time":"2002-09-30T00:00:00Z","timestamp":1033344000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2002,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Plasma cell neoplasia occurs much less frequently than high\u2010grade B\u2010cell non\u2010Hodgkins lymphoma in HIV\u2010infected patients, but is nevertheless an AIDS\u2010associated malignancy. In this report, we describe the fine\u2010needle aspiration (FNA) findings of a mass in the left parotid region with plasmablastic features that occurred in a 41\u2010yr\u2010old HIV\u2010infected homosexual man whom we diagnosed as having anaplastic myeloma. The patient had normochromic, normocytic anemia with a hematocrit of 21%, a white blood count of 2.2 \u00d7 10<jats:sup>9<\/jats:sup>\/l with 76% neutrophils, and a CD4 count of 31%. He also had elevated levels of calcium (13.2 mg\/dl), alkaline phosphatase (25,400 IU\/l), blood urea nitrogen (2,600 mg\/dl), and creatinine (2.5 mg\/dl). Serum protein electrophoresis showed polyclonal hypergammaglobulinemia without any monoclonal component. A bone survey revealed multiple punched\u2010out lytic lesions. FNA smears showed large plasmacytoid cells with eccentrically placed nuclei, prominent nucleoli, and moderate amounts of basophilic cytoplasm. By immunocytochemical staining, tumor cells were negative for CD19, CD20, and leukocyte\u2010common antigen (LCA), but strongly positive for CD38 and kappa light chain.<\/jats:p><jats:p>Anaplastic myeloma and plasmablastic lymphoma were considered in the differential diagnosis. Although the cytomorphologic and immunophenotypic findings of our case overlapped with those of plasmablastic lymphoma, the pattern of bone involvement with punched\u2010out lytic lesions and absence of localization of the tumor to the mucosa of the oral cavity led us to a diagnosis of anaplastic myeloma. The patient initially received antiretroviral therapy followed by thalidomide and pulse dexamethasome therapy, but his response was poor. His HIV load increased, and his malignancy rapidly progressed with the development of multiple vertebral lesions, extraosseous extension, and eventually cord compression. He died of the disease less than 2 mo after presentation. Diagn. Cytopathol. 2002;27:218\u2013222. \u00a9 2002 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.10174","type":"journal-article","created":{"date-parts":[[2002,10,9]],"date-time":"2002-10-09T05:10:41Z","timestamp":1034140241000},"page":"218-222","source":"Crossref","is-referenced-by-count":15,"title":["Fine\u2010needle aspiration cytology of a case of HIV\u2010associated anaplastic myeloma"],"prefix":"10.1002","volume":"27","author":[{"given":"John M.M.","family":"Stewart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savitri","family":"Krishnamurthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,9,30]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"390","article-title":"The epidemiology of acquired immunodeficiency syndrome malignancies","volume":"27","author":"Geodert JJ","year":"2000","journal-title":"Semin Oncol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.4.1413"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2400875"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/102.5.633"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(92)90189-W"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(86)90312-0"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1085-5629(97)80043-0"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.114.1.251"},{"key":"e_1_2_1_10_2","first-page":"129","article-title":"Parasitic infections associated with HIV\/AIDS in the Caribbean","volume":"29","author":"Robinson RD","year":"1995","journal-title":"Bull Pan Am Health Organ"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199504001-00001"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)09028-4"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000101)88:1<15::AID-CNCR4>3.0.CO;2-0"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900100209"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.5.1551"},{"key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1001\/archinte.1981.00340100071017","article-title":"Aggressive plasma cell myeloma\u2014a terminal phase","volume":"141","author":"Suchman AL","year":"1981","journal-title":"Arch Intern Med"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/07357909009012059"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1991.tb08620.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770000160"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1182\/blood.V91.3.984","article-title":"Application of interphase fluoresence in situ hybridization for the detection of the Burkitt translocation t(8;14) (q24; q32) in B\u2010cell lymphomas","volume":"91","author":"Seibert R","year":"1998","journal-title":"Blood"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.10174","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.10174","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T08:09:31Z","timestamp":1700294971000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.10174"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,9,30]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2002,10]]}},"alternative-id":["10.1002\/dc.10174"],"URL":"https:\/\/doi.org\/10.1002\/dc.10174","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,9,30]]}}}