{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:38:07Z","timestamp":1770989887780,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2002,12,30]],"date-time":"2002-12-30T00:00:00Z","timestamp":1041206400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our objective was to study the cytomorphological features of metastatic nasopharyngeal carcinoma (NPC) as compared to squamous\u2010cell carcinoma (SCC) of nonnasopharyngeal origin, Hodgkin's lymphoma (HL), and non\u2010Hodgkin's (NHL) lymphoma in the neck lymph nodes. The aim of this study was to find simple cytological criteria using routine stains that can help in differentiating between these entities. All fine\u2010needle aspiration (FNA) smears of metastatic NPC, SCC, HL, and NHL from neck nodes available in our files were included in this study. Nodal disease was the first clinical manifestation in all cases of NPC, and all the lesions were of the nonkeratinizing type. The cytomorphological features of metastatic NPC, SCC, HL, and NHL have been described. Metastatic NPC and HL had a similar reactive lymphoid background, with eosinophils, plasma cells, and sometimes epithelioid\u2010cell granulomas. The bizarre cells of NPC showed some resemblance to Reed\u2010Sternberg cells of HL. However, the latter can be distinguished from the former on the basis of bulky, pale gray, vacuolated cytoplasm and vesicular nuclei with sharply demarcated prominent macronucleoli. In NPC, the neoplastic cells form distinct aggregates contrasting with the normal lymphoid cells in the background, which was different from the monotonous dispersed population of cells in NHL. Moreover, bizarre cells, prominent nucleoli, and the presence of plasma cells, eosinophils, and granulomas were not common features of NHL. The smears of metastatic SCC revealed keratinized malignant cells in all cases, while eosinophils and plasma cells were absent in the background. Plasma cells were seen intimately related to tumor cells in all cases of NPC. In conclusion, metastatic NPC can be differentiated from metastatic SCC of nonnasopharyngeal origin, HL, and NHL on the basis of simple nuclear and cytoplasmic features of malignant cells and their background. The presence of plasma cells intermingling with tumor\u2010cell clusters is a good indicator of nasopharyngeal origin. On the other hand, a nasopharyngeal origin is unlikely in the presence of keratinized malignant cells. Diagn. Cytopathol. 2003;28:18\u201322. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.10218","type":"journal-article","created":{"date-parts":[[2003,1,1]],"date-time":"2003-01-01T02:22:25Z","timestamp":1041387745000},"page":"18-22","source":"Crossref","is-referenced-by-count":31,"title":["Fine\u2010needle aspiration cytology of metastatic nasopharyngeal carcinoma in cervical lymph nodes: Comparison with metastatic squamous\u2010cell carcinoma, and Hodgkin's and non\u2010Hodgkin's lymphoma"],"prefix":"10.1002","volume":"28","author":[{"given":"Sharanamma M.","family":"Kollur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imad Abdien","family":"El Hag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2002,12,30]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1177\/106689690000800107"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821001)50:7<1344::AID-CNCR2820500721>3.0.CO;2-O"},{"key":"e_1_2_1_4_2","first-page":"862","article-title":"Metastatic nasopharyngeal carcinoma initially presenting as cervical lymphadenopathy. A report of two cases that resemble Hodgkin's disease","volume":"116","author":"Zatate\u2010Osorno A","year":"1992","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_5_2","first-page":"4931","article-title":"Expression of cytokeratin and additional markers in undifferentiated lymph node metastases of the neck","volume":"20","author":"Bartel\u2010Friedrich S","year":"2000","journal-title":"Anticancer Res"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860901)58:5<1172::AID-CNCR2820580533>3.0.CO;2-1"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(88)90193-9"},{"key":"e_1_2_1_8_2","first-page":"344","article-title":"Fine needle aspiration cytodiagnosis of nasopharyngeal carcinoma in cervical lymph nodes. A study of 40 cases","volume":"33","author":"Chan MK","year":"1989","journal-title":"Acta Cytol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199809)19:3<168::AID-DC2>3.0.CO;2-9"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0347(200007)22:4<336::AID-HED4>3.0.CO;2-T"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.2880170606"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-000-0094-9"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01104.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199810000-00003"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.10218","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.10218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T18:02:00Z","timestamp":1700244120000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.10218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,12,30]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1002\/dc.10218"],"URL":"https:\/\/doi.org\/10.1002\/dc.10218","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,12,30]]}}}