{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T07:11:52Z","timestamp":1772953912862,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2003,11,19]],"date-time":"2003-11-19T00:00:00Z","timestamp":1069200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2003,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study addresses the utility of fine\u2010needle aspiration (FNA) in assessing lymphadenopathy in patients with and without a previous history of malignancy. We reviewed the FNAs of superficial and deeply seated lymph nodes performed at our institution over a period of 18 yr (1983\u20132001). Where applicable, we also reviewed and report here the results of subsequent surgical excisional biopsies. We analyzed data from 439 patients, who ranged in age from 1 to 90 yr. The neck and retroperitoneum were the most frequently sampled sites (47% and 25%, respectively). Among the 439 FNAs, adequate material was obtained in 421 cases (96%); the remaining 18 were unsatisfactory (4.1%). Malignant diagnoses were rendered in 330 cases (75% of 439), four were suspicious for lymphoma (0.9%), and 87 were read as reactive lymph nodes or granulomas (20%). The most common malignant cytologic diagnoses from these lymph node FNAs were adenocarcinoma, squamous cell carcinoma, and lymphoma. We compared results between two major groups: patients with a history of malignancy and those without. FNA showed malignancy in 87% of patients with a history of cancer and 41% without such a history. Thirty\u2010three or 10% of patients with a history of malignancy were given a benign diagnosis and follow\u2010up surgical excisional biopsies were performed in nine of these cases. Four of the nine showed low\u2010grade lymphoma. Of the 18 nondiagnostic FNAs, nine came from patients with a history of malignancy and in six of these nine who had a follow\u2010up surgical excisional biopsy the lymph nodes were positive for malignancy. Of the other nine, who had no history of malignancy, only two had follow\u2010up biopsies and both of these were negative. Patients with a history of malignancy are more than twice as likely to show malignancy on lymph node FNA compared to those without such a history (87% vs. 41%). Knowing whether a patient has a history of malignancy provides the appropriate level of suspicion for ordering ancillary investigations or even recommending excisional biopsy for further evaluation. Diagn. Cytopathol. 2003;29:315\u2013319. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.10346","type":"journal-article","created":{"date-parts":[[2003,12,2]],"date-time":"2003-12-02T14:16:20Z","timestamp":1070374580000},"page":"315-319","source":"Crossref","is-referenced-by-count":24,"title":["Fine\u2010needle aspiration of superficial and deeply seated lymph nodes on patients with and without a history of malignancy: Review of 439 cases"],"prefix":"10.1002","volume":"29","author":[{"given":"Kristian T.","family":"Schafernak","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry F.","family":"Kluskens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reshma","family":"Ariga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vijaya B.","family":"Reddy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Gattuso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2003,11,21]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.51.12.881"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.51.3.197"},{"key":"e_1_2_1_4_2","first-page":"76","article-title":"Fine needle aspiration biopsy in the diagnosis of lymphadenopathy in 1,103 patients: role, limitations and analysis of diagnostic pitfalls","volume":"39","author":"Steel BL","year":"1995","journal-title":"Acta Cytol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.8122112"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199612)15:5<382::AID-DC5>3.0.CO;2-E"},{"key":"e_1_2_1_7_2","first-page":"8","article-title":"Cytologic diagnosis of reactive lymphadenopathy in fine needle aspiration biopsy specimens","volume":"31","author":"Stani J","year":"1987","journal-title":"Acta Cytol"},{"key":"e_1_2_1_8_2","first-page":"311","article-title":"Morphologic and immunocytochemical evaluation of 220 fine needle aspirates of malignant lymphoma and lymphoid hyperplasia","volume":"34","author":"Sneige N","year":"1990","journal-title":"Acta Cytol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840915)54:6<1076::AID-CNCR2820540624>3.0.CO;2-W"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840010110"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1067\/mge.2001.112841"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.5858\/2000-124-1792-UOFCIF","article-title":"Utility of flow cytometry immunophenotyping for the diagnosis and classification of lymphoma in community hospital clinical needle aspiration\/biopsies","volume":"124","author":"Siebert JD","year":"2000","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199905)20:5<278::AID-DC6>3.0.CO;2-W"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.2000.00208.x"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.10346","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.10346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T23:51:13Z","timestamp":1700265073000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.10346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,21]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["10.1002\/dc.10346"],"URL":"https:\/\/doi.org\/10.1002\/dc.10346","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,11,21]]}}}