{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T09:40:39Z","timestamp":1778233239066,"version":"3.51.4"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2001,5,30]],"date-time":"2001-05-30T00:00:00Z","timestamp":991180800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2001,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the cytologic features of papillary carcinoma of the thyroid are well\u2010known, none is entirely specific. We conducted this study to determine the minimal criteria necessary to achieve 100% specificity for the diagnosis of papillary carcinoma on fine\u2010needle aspiration (FNA). Forty patients with histologically confirmed papillary carcinoma and 17 patients with other thyroid lesions who underwent preoperative FNA at Beth Israel Deaconess Medical Center during a 4\u2010yr period were included in the study. All cytology slides were prepared with the ThinPrep\u00ae processing technique. Various architectural and nuclear features were evaluated, with a score assigned to each feature, and correlated with the histologic diagnosis of papillary carcinoma. Intranuclear inclusions, papillary and\/or sheet arrangements, nuclear grooves, powdery chromatin, nuclear molding, high cellularity, and small nucleoli were significantly associated with papillary carcinoma (<jats:italic>P<\/jats:italic> &lt; 0.05). The requirement of any intranuclear inclusions and many nuclear grooves, or a minimum of sum of scores (of the above eight features) of 10, yields 100% specificity and approximately 70% sensitivity. Cases with fewer features can be reported as suspicious or indeterminate for papillary carcinoma. A quantitative\/probabilistic approach in the reporting of thyroid FNA provides a practical guide for management of patients with thyroid nodules. Diagn. Cytopathol. 24:378\u2013383, 2001. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.1084","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T20:40:11Z","timestamp":1030308011000},"page":"378-383","source":"Crossref","is-referenced-by-count":43,"title":["Morphologic predictors of papillary carcinoma on fine\u2010needle aspiration of thyroid with ThinPrep\u00ae preparations"],"prefix":"10.1002","volume":"24","author":[{"given":"Yilin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean L.","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen H.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,5,30]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199302253280807"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)46633-8"},{"key":"e_1_2_1_4_2","first-page":"850","article-title":"Sensitivity and specificity of fine needle aspiration cytology in the diagnosis of tumors of the thyroid gland","volume":"29","author":"Akerman M","year":"1985","journal-title":"Acta Cytol"},{"key":"e_1_2_1_5_2","first-page":"645","article-title":"Correlation of cytologic and histologic features in variants of papillary carcinoma of the thyroid","volume":"37","author":"Leung CS","year":"1993","journal-title":"Acta Cytol"},{"key":"e_1_2_1_6_2","first-page":"409","article-title":"Role of nuclear grooves in the diagnosis of papillary thyroid carcinoma. A quantitative assessment on fine needle aspiration smears","volume":"39","author":"Francis IM","year":"1995","journal-title":"Acta Cytol"},{"key":"e_1_2_1_7_2","first-page":"552","article-title":"Clear nuclei of papillary thyroid carcinoma conspicuous in fine\u2010needle aspiration and intraoperative smears processed by ultrafast Papanicolaou stain","volume":"10","author":"Yang GC","year":"1997","journal-title":"Mod Pathol"},{"key":"e_1_2_1_8_2","first-page":"21","article-title":"Nuclear grooves in the aspiration cytology of papillary carcinoma of the thyroid","volume":"33","author":"Rupp M","year":"1989","journal-title":"Acta Cytol"},{"key":"e_1_2_1_9_2","first-page":"16","article-title":"Nuclear grooves in cytologic preparations. A study of the utility of this feature in the diagnosis of papillary carcinoma","volume":"33","author":"Gould E","year":"1989","journal-title":"Acta Cytol"},{"key":"e_1_2_1_10_2","first-page":"691","article-title":"The significance of the grooved nucleus in thyroid lesions","volume":"6","author":"Scopa CD","year":"1993","journal-title":"Mod Pathol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980625)84:3<169::AID-CNCR9>3.0.CO;2-J"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/104.2.150"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199704)16:4<368::AID-DC14>3.0.CO;2-I"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980225)84:1<17::AID-CNCR4>3.0.CO;2-C"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326224"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200007)23:1<6::AID-DC2>3.0.CO;2-F"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840080106"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.1084","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.1084","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T13:53:44Z","timestamp":1700402024000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.1084"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,5,30]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2001,6]]}},"alternative-id":["10.1002\/dc.1084"],"URL":"https:\/\/doi.org\/10.1002\/dc.1084","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,5,30]]}}}