{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:25:07Z","timestamp":1770823507779,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,7,24]],"date-time":"2001-07-24T00:00:00Z","timestamp":995932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this report we describe the cytologic features of an unusual thymic carcinoid tumor containing prominent cytoplasmic lipid vacuoles that was diagnosed by fine\u2010needle aspiration biopsy. The tumor presented as a presternal subcutaneous mass in an 81\u2010yr\u2010old female, with a contiguous mediastinal mass on computed tomography. The cytomorphologic features included numerous discohesive cells with eccentric, round to oval nuclei, granular chromatin, and scant cytoplasm containing numerous intracytoplasmic, clear vacuoles. The neoplastic cells were reactive for neuroendocrine markers by immunocytochemistry and showed reactivity of the intracytoplasmic vacuoles with an oil red\u2010O stain for neutral lipid. Ultrastructural examination confirmed the presence of intracytoplasmic lipid vacuoles and neurosecretory granules. Subsequent surgical excision confirmed the diagnosis. We believe this to be the first report describing these features in a primary thymic carcinoid tumor. The differential diagnosis of mediastinal tumors with clear\u2010cell features and cytoplasmic vacuolization is also discussed. Diagn. Cytopathol. 2001;25:130\u2013133. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.2020","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:50:36Z","timestamp":1030312236000},"page":"130-133","source":"Crossref","is-referenced-by-count":13,"title":["Lipid\u2010rich carcinoid tumor of the thymus gland: Diagnosis by fine\u2010needle aspiration biopsy"],"prefix":"10.1002","volume":"25","author":[{"given":"Nancy L.","family":"Smith","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James L.","family":"Finley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,7,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197204)29:4<1061::AID-CNCR2820290456>3.0.CO;2-3"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199612)15:5<439::AID-DC17>3.0.CO;2-O"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199511000-00008"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870201)59:3<484::AID-CNCR2820590322>3.0.CO;2-C"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.3109\/01913128209016620"},{"key":"e_1_2_1_7_2","first-page":"423","article-title":"Fine needle aspiration cytology of thymic carcinoid tumor","volume":"39","author":"Wang DY","year":"1995","journal-title":"Acta Cytol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000333198"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198204000-00001"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197204)29:4<1075::AID-CNCR2820290457>3.0.CO;2-O"},{"key":"e_1_2_1_11_2","first-page":"35","article-title":"Neuroendocrine neoplasms of the mediastinum","volume":"8","author":"Wick MR","year":"1991","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_1_12_2","first-page":"32","article-title":"Primary neuroendocrine carcinomas of the thymus","volume":"16","author":"Klemm KM","year":"1999","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1309\/3PDN-PMT5-EQTM-H0CD"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199808000-00013"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1996.2230837.x"},{"key":"e_1_2_1_16_2","first-page":"18","article-title":"Primary carcinomas of the thymus gland","volume":"16","author":"Ritter JH","year":"1999","journal-title":"Semin Diagn Pathol"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.2020","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.2020","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T10:16:45Z","timestamp":1700389005000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.2020"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,24]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1002\/dc.2020"],"URL":"https:\/\/doi.org\/10.1002\/dc.2020","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,24]]}}}