{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:04:42Z","timestamp":1770822282109,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,7,24]],"date-time":"2001-07-24T00:00:00Z","timestamp":995932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2001,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The purpose of this study was to apply atypical squamous cells of undetermined significance (ASCUS) criteria from the Bethesda System for Reporting Cervical\/Vaginal Cytologic Diagnoses (TBS) to the rescreen of cases previously diagnosed as ASCUS, to compare initial and rescreen diagnoses, and to analyze agreement with follow\u2010up (cytology or histology). Two cytotechnologists (S.B. and M.J.M.) and one cytopathology fellow (M.A.) rescreened 632 cervicovaginal specimens diagnosed as ASCUS between June 1, 1992\u2013December 31, 1995. Age and LMP were provided. Rescreen diagnoses were categorized as within normal limits (WNL), ASCUS, low\u2010grade squamous intraepithelial lesions (LSIL), high\u2010grade squamous intraepithelial lesions (HSIL), or carcinoma (CA). Complete agreement was found in 200 specimens (32%): 31 (15%) WNL; 91 (45%) ASCUS; 77 (38.5%) SIL; and one (0.50%) CA. Follow\u2010up revealed no abnormality in 67% of the cases reclassified as WNL, 49% of the cases reclassified as ASCUS, and 48% of the cases reclassified as squamous intraepithelial lesions (SIL). SIL was found in 29% of cases reclassified as WNL, 29% of specimens rediagnosed as ASCUS, and 34% of cases reclassified as SIL. Partial agreement was found in 391 specimens (62%). In 41 specimens (6%), rescreeners were in complete disagreement, and follow\u2010up revealed 9\/41 (22%) SIL or worse; 21\/41 (51%) WNL; and 4\/41 (10%) inconclusive. Applying established criteria, 14% (91\/632) of cases diagnosed as ASCUS resulted in complete agreement, and 30% (190\/632) resulted in partial agreement. Follow\u2010up of cases initially diagnosed as ASCUS revealed SIL or CA in 30% of cases. ASCUS is a significant diagnosis warranting careful patient follow\u2010up. Diagn. Cytopathol. 2001;25:138\u2013140. \u00a9 2001 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.2022","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:50:36Z","timestamp":1030312236000},"page":"138-140","source":"Crossref","is-referenced-by-count":25,"title":["Smears diagnosed as ASCUS: Interobserver variation and follow\u2010up"],"prefix":"10.1002","volume":"25","author":[{"given":"Rose Marie","family":"Gatscha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Abadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia","family":"Babore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Chhieng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mara Jo","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia E.","family":"Saigo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,7,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/102.2.182"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(87)80004-2"},{"key":"e_1_2_1_4_2","first-page":"56","article-title":"Experience with 40,000 Papanicolaou smears","volume":"48","author":"Sandmire HF","year":"1976","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_5_2","first-page":"43","article-title":"Atypical squamous cells in Papanicolaou smears","volume":"69","author":"Davis GL","year":"1987","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000333166"},{"key":"e_1_2_1_7_2","first-page":"778","article-title":"Routine colposcopic survey of patients with squamous atypia: a method for identifying cases with false\u2010negative smears","volume":"34","author":"Cecchini S","year":"1990","journal-title":"Acta Cytol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199910)21:4<292::AID-DC13>3.0.CO;2-N"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(68)90187-7"},{"key":"e_1_2_1_10_2","first-page":"108","article-title":"Non\u2010diagnostic squamous atypia in cervico\u2010vaginal cytology as a risk factor for early neoplasia","volume":"20","author":"Melamed MR","year":"1976","journal-title":"Acta Cytol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.222.6.691"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840090410"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(87)90065-2"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199701)16:1<1::AID-DC2>3.0.CO;2-M"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840130418"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.2022","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.2022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T10:16:12Z","timestamp":1700388972000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.2022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,7,24]]},"references-count":14,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,8]]}},"alternative-id":["10.1002\/dc.2022"],"URL":"https:\/\/doi.org\/10.1002\/dc.2022","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,7,24]]}}}