{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:06:53Z","timestamp":1772118413360,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,8,2]],"date-time":"2005-08-02T00:00:00Z","timestamp":1122940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Detection of p16 is emerging as a useful biomarker for Human Papillomavirus (HPV)\u2010related dysplastic and malignant lesions of the cervix, and as such has potential application to cervicovaginal Papanicolaou (Pap) specimens. While evaluating p16 immunocytochemistry in our laboratory we observed one Pap test in which\n                    <jats:italic>Trichomonas vaginalis<\/jats:italic>\n                    stained positively for p16. We therefore proceeded to determine the frequency of\n                    <jats:italic>T. vaginalis<\/jats:italic>\n                    immunoreactivity for p16 in 10 consecutive, satisfactory, liquid\u2010based Pap tests diagnosed as negative for intraepithelial lesion or malignancy in which\n                    <jats:italic>T. vaginalis<\/jats:italic>\n                    was present. For each case, a ThinPrep\u2122 slide prepared from residual vial material was immunostained with p16. In an additional case, a prepared cell block was stained with p16.\n                    <jats:italic>T. vaginalis<\/jats:italic>\n                    were consistently p16 positive. We document, for the first time, p16 immunoreactivity of\n                    <jats:italic>T. vaginalis<\/jats:italic>\n                    that, on a Pap slide and cell block, may be morphologically misinterpreted as small dysplastic or malignant epithelial cells. The presence of this parasite in Pap tests may also potentially hinder the use of p16 as an adjunct to liquid\u2010based cervical screening cytology. Diagn. Cytopathol. 2005;33:210\u2013213. \u00a9 2005 Wiley\u2010Liss, Inc.\n                  <\/jats:p>","DOI":"10.1002\/dc.20349","type":"journal-article","created":{"date-parts":[[2005,8,3]],"date-time":"2005-08-03T16:23:48Z","timestamp":1123086228000},"page":"210-213","source":"Crossref","is-referenced-by-count":15,"title":["<i>Trichomonas vaginalis<\/i>\n                    P16 Immunoreactivity in cervicovaginal Pap tests: A diagnostic pitfall"],"prefix":"10.1002","volume":"33","author":[{"given":"Liron","family":"Pantanowitz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxanne R.","family":"Florence","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A.","family":"Goulart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher N.","family":"Otis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,8,2]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326578"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.1998.tb03954.x"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00479-7"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20122"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326711"},{"key":"e_1_2_1_7_2","first-page":"8","article-title":"P16INK4A as an adjunct test in liquid\u2010based cytology","volume":"25","author":"Bibbo M","year":"2003","journal-title":"Anal Quant Cytol Histol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.1.56"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10205"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.11589"},{"key":"e_1_2_1_11_2","first-page":"695","article-title":"Consistency of p16 staining in ThinPrep\u00ae slides and ThinPrep\u00ae vial derived cell blocks in biopsy proven CIN","volume":"48","author":"Angel A","year":"2004","journal-title":"Acta Cytol"},{"key":"e_1_2_1_12_2","first-page":"694","article-title":"Predictive value of p16INK4A in detection of CIN 2\/3 from high\u2010risk HPV positive ASC\u2010US: a biopsy comparison study","volume":"48","author":"Guo M","year":"2004","journal-title":"Acta Cytol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326312"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200302000-00006"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20046"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326445"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MP.0000077518.78046.0C"},{"issue":"4","key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1097\/00007435-199904001-00002","article-title":"Estimates of the incidence and prevalence of sexually transmitted diseases in the United States. American Social Health Association Panel","volume":"26","author":"Cates W","year":"1999","journal-title":"Sex Transm Dis"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00160311"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.20349","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.20349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T01:37:15Z","timestamp":1700185035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.20349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,2]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1002\/dc.20349"],"URL":"https:\/\/doi.org\/10.1002\/dc.20349","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.1027759.334766","asserted-by":"object"}]},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,8,2]]}}}