{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:19:49Z","timestamp":1770823189107,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,4,7]],"date-time":"2006-04-07T00:00:00Z","timestamp":1144368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acinar cell carcinoma (ACC) of the pancreas is extremely uncommon and its cytologic features have rarely been described. We describe the cytologic features of cases we have seen, review the literature regarding its cytologic features and discuss the pitfalls that may be encountered and the use of immunohistochemistry for its diagnosis. We searched our databases for all cases of histologically confirmed pancreatic ACC which had undergone prior fine needle aspiration (FNA) of the primary pancreatic lesion. The clinical histories, radiographic and sonographic findings, cytologic features, original cytologic diagnoses, and final histologic diagnoses were reviewed. Four cases of pancreatic ACC were found that had undergone FNA prior to histologic confirmation of the diagnoses. They were from 2 men and 2 women aged 50\u201375 yr. All masses were in the head of the pancreas, 2 had apparent peri\u2010pancreatic adenopathy and 1 had an apparent liver metastasis. On review, all 4 had had diagnostic material on cytology samples. Original cytologic diagnoses included \u201cacinar cell carcinoma,\u201d \u201cpancreatic endocrine tumor,\u201d \u201cfavor neuroendocrine tumor, low\u2010grade\u201d and \u201cnon\u2010diagnostic specimen.\u201d The cytologic features included small to moderate\u2010sized loose groups with numerous single cells, prominent acinar formation, little anisonucleosis and prominent nucleoli. The cytologic features showed significant overlap with those of pancreatic endocrine tumors. Diagn. Cytopathol. 2006; 34:367\u2013372. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.20450","type":"journal-article","created":{"date-parts":[[2006,4,7]],"date-time":"2006-04-07T23:47:53Z","timestamp":1144453673000},"page":"367-372","source":"Crossref","is-referenced-by-count":65,"title":["Cytology of pancreatic acinar cell carcinoma"],"prefix":"10.1002","volume":"34","author":[{"given":"Edward B.","family":"Stelow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo H.","family":"Bardales","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa M.","family":"Shami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolyn","family":"Woon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Presley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shawn","family":"Mallery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca","family":"Lai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael W.","family":"Stanley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,7]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1309\/MFRFJ0XYJLN8NVDP"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pap.0000155053.68496.ad"},{"key":"e_1_2_1_4_2","first-page":"655","article-title":"Fine needle aspiration cytology of neuroendocrine tumors of the pancreas. A cytologic, immunocytochemical and electron microscopic study","volume":"36","author":"al\u2010Kaisi N","year":"1992","journal-title":"Acta Cytol"},{"key":"e_1_2_1_5_2","first-page":"873","article-title":"Fine needle aspiration cytology of the pancreas. An analysis of its use in 52 patients","volume":"29","author":"Alpern GA","year":"1985","journal-title":"Acta Cytol"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199812)19:6<423::AID-DC4>3.0.CO;2-N"},{"key":"e_1_2_1_7_2","first-page":"39","article-title":"Fine needle aspiration of the pancreas. A five\u2010year experience","volume":"32","author":"Pinto MM","year":"1988","journal-title":"Acta Cytol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840030108"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840100414"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199607)15:1<37::AID-DC8>3.0.CO;2-N"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000333921"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1309\/DKK2B9V4N0W26A8Q"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20224"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199702)16:2<112::AID-DC3>3.0.CO;2-J"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199209000-00001"},{"key":"e_1_2_1_16_2","first-page":"241","volume-title":"Tumours of the digestive system","author":"Klimstra DL","year":"2000"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800356"},{"key":"e_1_2_1_18_2","first-page":"66","article-title":"Solid\u2010pseudopapillary tumor of the pancreas: a typically cystic carcinoma of low malignant potential","volume":"17","author":"Klimstra DS","year":"2000","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_1_19_2","first-page":"246","volume-title":"Tumours of the digestive system","author":"Kloppel G","year":"2000"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.20450","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.20450","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T17:27:18Z","timestamp":1696699638000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.20450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,7]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1002\/dc.20450"],"URL":"https:\/\/doi.org\/10.1002\/dc.20450","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,7]]}}}