{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:02:27Z","timestamp":1782363747868,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T00:00:00Z","timestamp":1155081600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence of glandular cervical malignancy is steadily increasing. Glandular abnormalities are more frequently diagnosed on cervical smears.<\/jats:p><jats:p>\u2003In this study, we attempt to evaluate our experience with glandular cytology and to assess the sensitivity and specificity of the ThinPrep (TP) over conventional Papanicolaou (Pap) smears.<\/jats:p><jats:p>\u2003Glandular abnormalities during a 3\u2010yr period from October 2000 to October 2003 were retrieved from our cytology database. The study group comprised smears from 369 patients, 272 conventional Pap smears (CPSs) and 97 TP from a total of 400,184 smears.<\/jats:p><jats:p>\u2003The types of glandular abnormalities were tabulated following a modified Bethesda classification. Correlation with histology and follow\u2010up cytology was achieved in all but six patients.<\/jats:p><jats:p>\u2003Significant lesions were identified in 116\/272 (PPV 42.6%) of CPSs and 58\/97 (PPV 58.9%) TPs. Pure glandular abnormalities numbered 125 conventional and 51 TP; significant lesions identified in this group were 36\/125 (PPV 28.8%) CPS and 26\/51 (PPV 50.9%) TP.<\/jats:p><jats:p>\u2003Statistical analysis showed significant differences for positive predictive values of TP and CPS and a suggestion of increased sensitivity. The main limiting factor was small numbers of glandular abnormalities and a desirable longer study time. Diagn. Cytopathol. 2006;34:614\u2013619. \u00a9 2006 Wiley\u2013Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.20509","type":"journal-article","created":{"date-parts":[[2006,8,9]],"date-time":"2006-08-09T16:58:34Z","timestamp":1155142714000},"page":"614-619","source":"Crossref","is-referenced-by-count":15,"title":["Accuracy of diagnosis of atypical glandular cells\u2014Conventional and ThinPrep"],"prefix":"10.1002","volume":"34","author":[{"given":"Reena","family":"Ramsaroop","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ien","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,8,9]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"8","article-title":"The validation of cervical cytology: Sensitivity, specificity, and predictive values","volume":"35","author":"Soost HJ","year":"1992","journal-title":"Acta Cytol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/101.2.215"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-8258(03)00176-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200007)23:1<19::AID-DC4>3.0.CO;2-K"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000330872"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11856"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10312"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0339(200010)23:4<260::AID-DC9>3.0.CO;2-Y"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5826"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.11826"},{"key":"e_1_2_1_12_2","first-page":"346","article-title":"Clinical significance and management of cervical atypical glandular cells of undermined significance","volume":"9","author":"Chan CW","year":"2003","journal-title":"Hong Kong Med J"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601874"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1092-9134(98)80024-5"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/S1701-2163(16)30136-0","article-title":"The relationship between atypical glandular cells of undetermined significance on Pap smear and a clinically significant histologic diagnosis","volume":"26","author":"Barreta D","year":"2004","journal-title":"J Obstet Gynaecol Can"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326860"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10761"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.20509","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.20509","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T15:59:45Z","timestamp":1700063985000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.20509"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8,9]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2006,9]]}},"alternative-id":["10.1002\/dc.20509"],"URL":"https:\/\/doi.org\/10.1002\/dc.20509","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8,9]]}}}