{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:05:42Z","timestamp":1763967942385},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T00:00:00Z","timestamp":1168992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Spindle epithelial tumor with thymus\u2010like differentiation (SETTLE) is a rare biphasic tumor of the thyroid with \u223c20 well\u2010documented cases reported in the English literature. Although a monophasic variant of SETTLE is conceivable, the majority of the reported cases were truly biphasic tumors. A minimal amount of epithelial component was present in the reported cases of so\u2010called spindle\u2010cell predominant SETTLE. Here, we report an apparently monophasic case of SETTLE in a 16\u2010yr\u2010old girl, in which no epithelial cells were identified in either fine\u2010needle aspiration biopsy (FNAB) or the subsequent hemithyroidectomy specimen. The FNAB smears were moderately cellular and composed of single and loosely grouped spindle cells with homogenous metachromatic material, which could be mistaken as amyloid, erroneously suggesting medullary thyroid carcinoma. The compact nodules of uniform spindle cells in histology sections raised the possibility of monophasic synovial sarcoma. The spindle cells stained positive for both cytokeratin and vimentin, but were negative for thyroglobulin and calcitonin as well as neuroendocrine markers, confirming the diagnosis of SETTLE. Diagn. Cytopathol. 2007;35:113\u2013119. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.20579","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T02:17:59Z","timestamp":1169086679000},"page":"113-119","source":"Crossref","is-referenced-by-count":32,"title":["Fine\u2010needle aspiration biopsy of monophasic variant of spindle epithelial tumor with thymus\u2010like differentiation of the thyroid: Report of one case and review of the literature"],"prefix":"10.1002","volume":"35","author":[{"given":"Guo\u2010Xia","family":"Tong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Hamele\u2010Bena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Jun","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"O'Toole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90083-2"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1968.2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/lary.5540861212"},{"key":"e_1_2_1_5_2","first-page":"109","article-title":"Malignant teratomas of the thyroid gland in an adolescent female","volume":"29","author":"Murao T","year":"1979","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198507000-00007"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1385\/EP:16:2:139"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1053\/hn.1999.v120.a85593"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1998.00441.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880212"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10024-005-0011-1"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00185397"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10111"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10107"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(03)00153-5"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1177\/106689699600400306"},{"key":"e_1_2_1_17_2","first-page":"510","article-title":"Spindle epithelial tumor with thymus\u2010like differentiation: A case report with cytologic, histologic, immunohistologic, and ultrastructural findings","volume":"10","author":"Su L","year":"1997","journal-title":"Mod Pathol"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2003.29"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199906000-00011"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10615"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200111000-00011"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/111.1.70"},{"key":"e_1_2_1_23_2","first-page":"123","article-title":"Undifferentiated and poorly differentiated carcinoma","volume":"2","author":"Rosai J","year":"1985","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_1_24_2","first-page":"135","volume-title":"Atlas of tumor pathology","author":"Rosai J","year":"1992"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/95.3.309"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1309\/XFN3-2E1B-21VW-8X28"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326399"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840080107"},{"key":"e_1_2_1_29_2","first-page":"920","article-title":"Fine needle aspiration of medullary carcinoma of the thyroid. 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