{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:45:45Z","timestamp":1747201545317},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,17]],"date-time":"2007-01-17T00:00:00Z","timestamp":1168992000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Extranodal natural killer (NK)\/T\u2010cell lymphoma of the nasal type is a rare type of malignant lymphoma that is most common in Asian countries. Here we describe cytomorphologic, immunocytochemical, and molecular cytochemical features of three cases of NK\/T\u2010cell lymphoma of the nasal type diagnosed by nasal brush cytology. Cytomorphologic findings common among the three cases included the presence of several cell types, including nasal cavity epithelial cells, histiocytes, phagocytic histiocytes, and lymphoid cells, within a necrotic background. Suspected lymphoma cells were medium to large lymphoid cells possessing light blue and abundant cytoplasm. A characteristic feature of these cells was the presence of the tongue\u2010like projections of cytoplasm from one or both sides of the cells. We believe these intriguing cytologic findings are indicators of NK\/T\u2010cell lymphoma of the nasal type. Azurophilic granules were observed in all cases, ranging from extremely fine granules to large granular lymphocyte (LGL)\u2010like granules. Immunocytochemical and molecular cytochemical analyses showed staining for natural killer cell antigen CD56 as well as cytotoxic granule\u2010associated proteins granzyme B7 (GrB7) and T\u2010cell\u2010restricted intercellular antigen\u20101 (TIA\u20101). EBV (Epstein\u2010Barr virus) encoded small RNAs (EBER) positivity was shown by in situ hybridization, and no rearrangement of the <jats:italic>TCR<\/jats:italic>\u03b3 gene was observed. Comparison between cytobrush and cotton swab methodology showed that cytobrush resulted in more cell\u2010rich specimens than did cotton swabs, suggesting that nasal brush cytology with cytobrush is most useful in the diagnosis of NK\/T\u2010cell lymphoma of the nasal type. Diagn. Cytopathol. 2007;35:125\u2013129. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.20604","type":"journal-article","created":{"date-parts":[[2007,1,18]],"date-time":"2007-01-18T02:19:37Z","timestamp":1169086777000},"page":"125-129","source":"Crossref","is-referenced-by-count":12,"title":["Three cases of extranodal NK\/T\u2010cell lymphoma of the nasal type diagnosed by nasal brush cytology"],"prefix":"10.1002","volume":"35","author":[{"given":"Koji","family":"Kishimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiko","family":"Hirayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Genshu","family":"Tate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiyuki","family":"Mitsuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,17]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1182\/blood.V84.5.1361.1361","article-title":"A revised European\u2010American classification of lymphoid neoplasma; a proposal from the international lymphoma study group","volume":"84","author":"Harris NL","year":"1994","journal-title":"Blood"},{"key":"e_1_2_1_3_2","first-page":"204","volume-title":"World health organization classification of tumours. Pathology and genetics of tumors of hematopoietic and lymphoid tissue","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10885"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/10245330400026162"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326574"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326648"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1159\/000327063"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.5795\/jjscc.22.192"},{"key":"e_1_2_1_10_2","first-page":"1030","article-title":"Lymph node smears in the diagnosis of lymphadenopathy","volume":"10","author":"Lucas PF","year":"1955","journal-title":"A review"},{"key":"e_1_2_1_11_2","first-page":"196","article-title":"Clonality assessment of T, NK\/T\u2010cell lymphoma\u2014Comparisons among primer sets and analyses of the limit to detect rearranged T\u2010cell receptor\u2010gamma genes","volume":"55","author":"Hirayama Y","year":"2006","journal-title":"Jpn J Med Technol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199408000-00001"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2003.01602.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.5795\/jjscc.27.7"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428199909169621"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1998.16.1.70"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.20604","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.20604","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T12:34:48Z","timestamp":1700051688000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.20604"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,17]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1002\/dc.20604"],"URL":"https:\/\/doi.org\/10.1002\/dc.20604","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,17]]}}}