{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:38:08Z","timestamp":1791859088673,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2007,8,15]],"date-time":"2007-08-15T00:00:00Z","timestamp":1187136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Within a multicentre controlled trial framework, an external quality control (EQC) was scheduled to evaluate the interlaboratory reproducibility of liquid\u2010based cytology. In particular, this EQC intended to evaluate the reproducibility of the ASCUS diagnosis.<\/jats:p><jats:p>A selected set of 30 slides (4 within normal limit cases, 16 atypical squamous cells of undetermined significance; 4 low\u2010grade squamous intraepithelial lesions and 6 high\u2010grade squamous intraepithelial lesions) circulated among the 13 laboratories involved in the trial.<\/jats:p><jats:p>Kappa values were obtained from the comparison between individual laboratory diagnoses and majority diagnoses with target diagnoses. Specific kappa values resulted moderate to high for HSIL and low to moderate for LSIL and WNL. Meanwhile, the specific kappa for ASCUS was below 0.4 in 12 of 13 participating laboratories.<\/jats:p><jats:p>The lack of reproducibility for ASCUS was not a result of the introduction of this new technology but rather to the low reproducibility of the ASCUS category itself stemming from intrinsic uncertainties in the reporting criteria. Diagn. Cytopathol. 2007;35:541\u2010544. \u00a9 2007 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.20681","type":"journal-article","created":{"date-parts":[[2007,8,16]],"date-time":"2007-08-16T15:47:38Z","timestamp":1187279258000},"page":"541-544","source":"Crossref","is-referenced-by-count":19,"title":["Interlaboratory reproducibility of liquid\u2010based equivocal cervical cytology within a randomized controlled trial framework"],"prefix":"10.1002","volume":"35","author":[{"given":"M.","family":"Confortini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bondi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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