{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T15:12:08Z","timestamp":1770822728917,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2008,1,29]],"date-time":"2008-01-29T00:00:00Z","timestamp":1201564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Cytyc ThinPrep Imaging System was FDA approved based on a multi\u2010institutional clinical trial, in which the HSIL+ prevalence rate was 0.7%. This study determines the effectiveness of the Imager in clinical practice at an academic medical center with a historical HSIL+ rate of 0.25%. Cytological interpretations were compared for two 12\u2010month periods pre\u2010 and post\u2010Imager implementation. Data was compiled by cytologic diagnoses, and variations in prevalence rates were analyzed for statistical significance. Interpretations of ASC\u2010US, ASC\u2010H, and LSIL were correlated with Digene Hybrid Capture2 High Risk HPV DNA testing; interpretations of ASC\u2010H, LSIL, and HSIL+ were correlated with subsequent surgical follow\u2010up. ASC\u2010US, ASC\u2010H, and LSIL detection rates increased 34, 48, and 29%, respectively, with the Imager (<jats:italic>P<\/jats:italic> &lt; 0.001); whereas the detection of HSIL increased 24% (<jats:italic>P<\/jats:italic> &lt; 0.051). Surgical correlation revealed no statistical differences in the positive predictive value (PPV) for ASC\u2010H and LSIL. However, an increase in the PPV of HSIL was found (<jats:italic>P<\/jats:italic> &lt; 0.05). High risk HPV results were lower for ASC\u2010US (<jats:italic>P<\/jats:italic> &lt; 0.001), but statistically equivalent for ASC\u2010H and LSIL. Results of surgical correlation and HPV testing validated an increase in detection rates of ASC\u2010H, LSIL, and HSIL, as well as increased PPV of HSIL with the ThinPrep Imaging System. Diagn. Cytopathol. 2008;36:155\u2013160. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.20779","type":"journal-article","created":{"date-parts":[[2008,1,29]],"date-time":"2008-01-29T20:48:46Z","timestamp":1201639726000},"page":"155-160","source":"Crossref","is-referenced-by-count":33,"title":["Effectiveness of the ThinPrep Imaging System: Clinical experience in a low risk screening population"],"prefix":"10.1002","volume":"36","author":[{"given":"Jacalyn L.","family":"Papillo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy L.","family":"St. John","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladwyn","family":"Leiman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,1,29]]},"reference":[{"key":"e_1_2_1_2_2","unstructured":"Operation Summary and Clinical Information [ThinPrep Imaging System] Cytyc Corporation Part No. 86093\u2010001 Rev. E00 2006."},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1159\/000325959"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.07.025"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20627"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1309\/AGB1MJ9H5N43MEGX"},{"key":"e_1_2_1_7_2","first-page":"700","article-title":"Impact of the ThinPrep imaging system on detection rates of cervical abnormalities (abstr)","volume":"48","author":"Qureshi MN","year":"2004","journal-title":"Acta Cytol"},{"key":"e_1_2_1_8_2","first-page":"701","article-title":"Comparison of manual and imaging\u2010directed screening of the ThinPrep Pap test in a large metropolitan cytology practice (abstr)","volume":"48","author":"Miller FS","year":"2004","journal-title":"Acta Cytol"},{"key":"e_1_2_1_9_2","first-page":"702","article-title":"Impact of the ThinPrep imaging system on the detection of cervical abnormalities (abstr)","volume":"48","author":"Iverson DK","year":"2004","journal-title":"Acta Cytol"},{"key":"e_1_2_1_10_2","first-page":"389","article-title":"Automated imaging\u2014The impact on cervical Pap test screening: A single institution experience (abstr)","volume":"105","author":"Elishaev E","year":"2005","journal-title":"Cancer Cytopathol"},{"key":"e_1_2_1_11_2","first-page":"363","article-title":"Impact on detection of cytologic abnormality rates after implementation of the ThinPrep imaging system at a medium volume privately owned reference laboratory (abstr)","volume":"108","author":"Travers H","year":"2006","journal-title":"Cancer Cytopathol"},{"key":"e_1_2_1_12_2","first-page":"379","article-title":"Increased disease detection: A comparison between ThinPrep imaging system review and manual review of ThinPrep Pap tests (abstr)","volume":"108","author":"Ramey L","year":"2006","journal-title":"Cancer Cytopathol"},{"key":"e_1_2_1_13_2","first-page":"364","article-title":"Imaging\u2010directed cytology increases ASCUS detection rate, but not hrHPV detection rate (abstr)","volume":"105","author":"Geyer SJ","year":"2005","journal-title":"Cancer Cytopathol"},{"key":"e_1_2_1_14_2","first-page":"400","article-title":"Age stratified ASC\u2010US high risk HPV positivity: Post implementation correlation of the ThinPrep imaging system with HPV findings (abstr)","volume":"108","author":"Ashfaq R","year":"2006","journal-title":"Cancer Cytopathol"},{"key":"e_1_2_1_15_2","first-page":"391","article-title":"Increased detection of cervical abnormality with the ThinPrep imaging system: A comparative analysis of over one million Pap tests (abstr)","volume":"108","author":"Linder J","year":"2006","journal-title":"Cancer Cytopathol"},{"key":"e_1_2_1_16_2","first-page":"664","article-title":"ThinPrep imaging system performance in the diagnosis of uncommon malignancies (abstr)","volume":"48","author":"Sabo D","year":"2004","journal-title":"Acta Cytol"},{"key":"e_1_2_1_17_2","first-page":"374","article-title":"Detection of adenocarcinoma using the ThinPrep imaging system (abstr)","volume":"105","author":"Sabo D","year":"2005","journal-title":"Cancer Cytopathol"},{"key":"e_1_2_1_18_2","first-page":"361","article-title":"ThinPrep imaging system effectiveness in the detection of glandular abnormalities (abstr)","volume":"108","author":"Friedlander MA","year":"2006","journal-title":"Cancer Cytopathol"},{"key":"e_1_2_1_19_2","first-page":"387","article-title":"Detection of endocervical adenocarcinoma in situ using the ThinPrep imaging system (abstr)","volume":"108","author":"Sabo D","year":"2006","journal-title":"Cancer Cytopathol"},{"key":"e_1_2_1_20_2","first-page":"353","article-title":"Comparison of quality control discrepancies in LSIL or above: Imaged versus non\u2010imaged slides (abstr)","volume":"105","author":"Miller FS","year":"2005","journal-title":"Cancer Cytopathol"},{"key":"e_1_2_1_21_2","first-page":"366","article-title":"The false\u2010negative rate of the ThinPrep imaging system compares favourably with manual screening (abstr)","volume":"105","author":"Kindelberger D","year":"2005","journal-title":"Cancer Cytopathol"},{"key":"e_1_2_1_22_2","first-page":"402","article-title":"A large reference Lab's experience with the ThinPrep imaging system (abstr)","volume":"108","author":"Chase J","year":"2006","journal-title":"Cancer Cytopathol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1159\/000326001"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20640"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39219.645475.55"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20600"},{"key":"e_1_2_1_27_2","first-page":"954","article-title":"Effective screening programmes for cervical cancer in low and 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