{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:23:52Z","timestamp":1780500232040,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T00:00:00Z","timestamp":1208304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>For cervical cancer screening, HPV\u2010DNA test is expensive and is not easily available in all clinical situations. Thus, we investigated the role of p16<jats:sup>ink4a<\/jats:sup> immunostaining as another adjunct test to diagnose cervical neoplasia in equivocal liquid based cytology. Eighty\u2010seven patients were randomly selected for this study (3 patients with normal, 84 patients with abnormal including 24 ASCUS, 30 LSIL, and 30 HSIL). We performed p16<jats:sup>ink4a<\/jats:sup> immunostaining on ThinPrep\u00ae slide and on each case from the corresponding cervical biopsy tissues. High\u2010risk HPV\u2010DNA testing was also performed on all the subjects. We found that the immunoreactivity of p16<jats:sup>ink4a<\/jats:sup> is strongly correlated with the grade of cytologic and histologic diagnoses as well as with Hybrid Capture 2. In comparing the p16<jats:sup>ink4a<\/jats:sup> immunostaining with the Hybrid Capture 2 for accuracy of the diagnosis of CIN II\/III or a higher\u2010grade disease in the case of ASCUS\/LSIL on ThinPrep\u00ae, no significant differences were observed. Our data implies that p16<jats:sup>ink4a<\/jats:sup> immunocytochemical staining in liquid\u2010based cytology specimens might be used as a good adjunct test to predict cervical histology in equivocal ThinPrep\u00ae tests. Diagn. Cytopathol. 2008;36:311\u2013316. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.20786","type":"journal-article","created":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T19:16:26Z","timestamp":1208373386000},"page":"311-316","source":"Crossref","is-referenced-by-count":6,"title":["Immunocytochemical staining of p16<sup>ink4a<\/sup> protein as an adjunct test in equivocal liquid\u2010based cytology"],"prefix":"10.1002","volume":"36","author":[{"given":"Eun Kyoung","family":"Shin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sa Ra","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi Kyoung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun 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