{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:48:01Z","timestamp":1761518881149,"version":"3.34.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T00:00:00Z","timestamp":1208304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2008,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Adult granulosa cell tumor (GCT) of the ovary is mostly diagnosed in postmenopausal women. They typically secrete estrogen, which stimulates the endometrium to proliferate and cause abnormal bleeding. This study reviews the cytologic features of adult GCT of the ovary diagnosed by fine\u2010needle aspiration (FNA). We reviewed slides from ten cases diagnosed by CT guided FNA from 1995 to 2007 at our institutions. Smears were stained with Diff\u2010Quik and Papanicolaou stains. Patient's history and histologic diagnosis were also available and reviewed for all cases. The patients ranged in age from 39 to 83 yr. All 10 cases were hypercellular with both large and small overlapping cell clusters and individual cells. The cytologic features identified included: naked nuclei (10\/10 cases), Call\u2010Exner bodies (7\/10 cases), blood vessels with prominent perivascular tumor cell growth (4\/10 cases), spindle\u2010shaped hyperchromatic stromal cells within cellular clusters (6\/10 cases), mixed inflammation (3\/10 cases), tumor cell necrosis (1\/10 cases), and prominent metachromatic stroma seen in association with blood vessels (1\/10 cases). Moderate to scant delicate cytoplasm was also seen (10\/10 cases). Small, punctuate cytoplasmic vacuoles were also noted (7\/10 cases) and were occasionally prominent (3\/10 cases). In general nuclear to cytoplasmic ratios were high although lower than those typically seen in a lymphoma or small\u2010cell carcinoma. Nuclei were generally centrally located although eccentrically located nuclei were consistently seen in a minority of cells. Nuclei were monotonous in size showing slightly convoluted (occasional rentiform and fetiform nuclei) to polygonal outlines. Prominent, central nucleoli were also seen (4\/10 cases). Nuclear grooves were also seen (9\/10 cases). No atypical mitotic activity was identified in any of the 10 cases (0\/10 cases). In summary, the above cytologic features can also help in the cytologic diagnosis of adult GCTs. Diagn. Cytopathol. 2008;36:297\u2013302. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.20798","type":"journal-article","created":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T16:46:57Z","timestamp":1208364417000},"page":"297-302","source":"Crossref","is-referenced-by-count":30,"title":["Adult granulosa cell tumor of the ovary: Fine\u2010needle\u2010aspiration cytology of 10 cases and review of literature"],"prefix":"10.1002","volume":"36","author":[{"given":"Sarfraz","family":"Ali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Gattuso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Howard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina B.","family":"Mosunjac","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Momin T.","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,4,16]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"783","volume-title":"Blaustein's pathology of the female genital tract","author":"Kurman RJ","year":"1996"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(83)90083-5"},{"key":"e_1_2_1_4_2","first-page":"231","article-title":"Clinicopathologic review of 118 granulosa and 82 theca cell tumors","volume":"55","author":"Evans AT","year":"1980","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197501)35:1<231::AID-CNCR2820350128>3.0.CO;2-O"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0936-6555(98)80008-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970515)79:10<1951::AID-CNCR16>3.0.CO;2-U"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930550203"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1994.1010"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(79)90090-8"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91071-S"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198703123161102"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198408000-00002"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.1060"},{"key":"e_1_2_1_15_2","series-title":"Endocrinology","first-page":"2113","author":"Idem","year":"1995"},{"key":"e_1_2_1_16_2","first-page":"786","article-title":"Androgenic granulosa cell tumors of the ovary. 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