{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:39:19Z","timestamp":1760297959642},"reference-count":48,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T00:00:00Z","timestamp":1212537600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2008,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objectives of the study were to evaluate 1) the diagnostic sensitivity and specificity of p16<jats:sup>INK4a<\/jats:sup> as a marker for high\u2010grade cervical lesions, 2) the results of a real\u2010time polymerase chain reaction detecting high\u2010risk human papillomavirus, and 3) the interobserver variability of the p16<jats:sup>INK4a<\/jats:sup> interpretation.<\/jats:p><jats:p>A total of 232 ThinPrep samples were stained for p16<jats:sup>INK4a<\/jats:sup>, and HPV\u2010DNA PCR was performed on 107 specimens with inclusion of both benign and abnormal cytology. Histological follow\u2010up information was collected.<\/jats:p><jats:p>The diagnostic sensitivity of ASC+ with CIN2+ in histology as endpoint was 96% for p16<jats:sup>INK4a<\/jats:sup> and 100% for HR\u2010HPV DNA PCR, and the diagnostic specificity was 41% and 27%, respectively. If p16<jats:sup>INK4a<\/jats:sup> had been used for triage of the ASC samples, then 18 patients (42%) could have been spared unnecessary follow\u2010up procedures compared to six patients (21%) with the HR\u2010HPV DNA test. Diagn. Cytopathol. 2008;36:453\u2013459. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.20822","type":"journal-article","created":{"date-parts":[[2008,6,4]],"date-time":"2008-06-04T20:53:21Z","timestamp":1212612801000},"page":"453-459","source":"Crossref","is-referenced-by-count":16,"title":["Are adjunctive markers useful in routine cervical cancer screening? 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