{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T10:20:47Z","timestamp":1756462847793},"reference-count":12,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T00:00:00Z","timestamp":1222819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2008,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report a 29\u2010year\u2010old woman who underwent routine gynecologic evaluation at a community clinic and had a cervical sample drawn for liquid\u2010based cytologic evaluation. At cytology, many hyperchromatic crowded groups (HCG) were present, but a consensus could not be established whether the abnormal cells were primarily glandular or squamous with secondary endocervical glandular involvement. An interpretation of atypical endocervical cells, favor neoplastic, was rendered and biopsy advised if clinically appropriate. At biopsy, the cervix contained synchronous squamous cell carcinoma in situ, secondarily involving endocervical glands, and neighboring adenocarcinoma in situ. Immunohistochemistry for Ki\u201067 and p16<jats:sup>INK4A<\/jats:sup> crisply and precisely stained both the lesions, clearly separating them from the adjacent uninvolved mucosa. This case re\u2010emphasizes the challenge associated with accurate evaluation of HCG at cytology, the significance of ancillary testing for surrogate markers of high\u2010risk HPV (HR\u2010HPV) infection, the need for adjunct testing for HPV\u2010DNA in the setting of HCG at cervical cytology, and a recommendation to set up studies to evaluate the role of surrogate markers of HR\u2010HPV infection in cytologic samples with HCG. Diagn. Cytopathol. 2008;36:823\u2013826. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.20932","type":"journal-article","created":{"date-parts":[[2008,10,1]],"date-time":"2008-10-01T17:11:44Z","timestamp":1222881104000},"page":"823-826","source":"Crossref","is-referenced-by-count":4,"title":["Synchronous high\u2010grade squamous intraepithelial lesion and adenocarcinoma in situ of cervix in a young woman presenting with hyperchromatic crowded groups in the cervical cytology specimen: Report of a case"],"prefix":"10.1002","volume":"36","author":[{"given":"Nadeem","family":"Zafar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louisa","family":"Balazs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara D.","family":"Benstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"93","volume-title":"The art and science of cytopathology","author":"DeMay RM","year":"1996"},{"key":"e_1_2_1_3_2","first-page":"182","volume-title":"The Pap test","author":"DeMay RM","year":"2005"},{"key":"e_1_2_1_4_2","first-page":"S36","article-title":"Pitfall in pap smear diagnosis","volume":"114","author":"DeMay RM","year":"2000","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.pcr.0000163430.15486.1a"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200107000-00006"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23255"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20770"},{"key":"e_1_2_1_10_2","first-page":"397","article-title":"The Cytologic diagnosis of adenocarcinoma in\u2010situ of the cervix uteri and related lesions. I. Adenocarcinoma in situ","volume":"31","author":"Ayer B","year":"1987","journal-title":"Acta Cytol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800316"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20589"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.2000.5826"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.20932","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.20932","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:37:27Z","timestamp":1700008647000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.20932"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10]]},"references-count":12,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["10.1002\/dc.20932"],"URL":"https:\/\/doi.org\/10.1002\/dc.20932","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10]]}}}