{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T03:28:08Z","timestamp":1768706888354,"version":"3.49.0"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,10,29]],"date-time":"2008-10-29T00:00:00Z","timestamp":1225238400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2009,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Diagnosis of two distinct malignant entities existing concurrently and at the same location (synchronous malignancy) by fine\u2010 needle aspiration (FNA) is unusual but may occur. Small lymphocytic lymphoma\/chronic lymphocytic leukemia (SLL\/CLL) in particular is associated with an increased incidence of secondary tumor, likely due to associated immunodeficiency. Co\u2010occurrence of some carcinomas such as squamous cell carcinoma (SCC), may show especially aggressive behavior. A 57\u2010year\u2010old Caucasian male presented with recurrent upper extremity lymphedema and diffuse lymphadenopathy of the axillary and cervical regions. FNA of a large cervical lymph node was diagnostic for both atypical lymphocytic proliferation and SCC. Flow cytometric analysis showed the atypical lymphocytic proliferation to be positive for CD5, CD23, CD19, CD20, HLA\u2010DR, CD38, and the population was kappa light chain restricted. These cells were negative for CD\u201010 and FMC\u20107 antigens, suggesting a phenotype of B\u2010cell SLL\/CLL. We report a rare occurrence of metastatic SCC to a lymph node infiltrated by SLL\/CLL. The diagnosis was achieved by a combination of cytomorphologic examination of FNA smears, immunohistochemical staining of cell block material, and flow cytometry on the sample obtained by FNA. To the best of our knowledge, only three cases of SCC metastasis to SLL\/CLL diagnosed by FNA have been reported in the English literature. Though rare, awareness of such a possibility and careful cytological examination under the appropriate clinical conditions is warranted. Diagn. Cytopathol. 2009. \u00a9 2008 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.20955","type":"journal-article","created":{"date-parts":[[2008,10,29]],"date-time":"2008-10-29T16:23:21Z","timestamp":1225297401000},"page":"48-50","source":"Crossref","is-referenced-by-count":9,"title":["Fine\u2010needle aspiration diagnosis of squamous cell carcinoma in a lymph node involved with small lymphocytic lymphoma: Case report and review of the literature"],"prefix":"10.1002","volume":"37","author":[{"given":"Clinton","family":"McElroy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rowena","family":"Velilla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Humera","family":"Chaudhary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mousa A.","family":"Al\u2010Abbadi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2008,10,29]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.75.2.174"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870201)59:3<540::AID-CNCR2820590330>3.0.CO;2-U"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/jso.2930330108"},{"key":"e_1_2_1_5_2","first-page":"232","article-title":"Squamous cell carcinoma metastasis to lymph nodes in chronic lymphatic leukemia","author":"Villet WT","year":"1977","journal-title":"S Afr Med J"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(85)70081-3"},{"key":"e_1_2_1_7_2","first-page":"407","article-title":"Fine needle aspiration of squamous cell carcinoma of the skin metastatic to the site of leukemic lymphadenopathy","volume":"36","author":"Soares FA","year":"1992","journal-title":"Acta Cytol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.5858\/2001-125-0799-SCCDBH"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.12.970"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199710)17:4<287::AID-DC9>3.0.CO;2-9"},{"key":"e_1_2_1_11_2","first-page":"210","article-title":"Synchronous cancer of squamous cell carcinoma of the lung and lymphocytic leukemia (b\u2010cell type): A case report","volume":"22","author":"Fukaura A","year":"1992","journal-title":"Jpn J Clin Oncol"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.11.021"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2006.00288.x"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199810000-00019"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2005.08.055"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.127.4.1152"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199803)18:3<184::AID-DC4>3.0.CO;2-E"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.20955","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.20955","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T16:10:22Z","timestamp":1700064622000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.20955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,10,29]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,1]]}},"alternative-id":["10.1002\/dc.20955"],"URL":"https:\/\/doi.org\/10.1002\/dc.20955","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,10,29]]}}}