{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T05:57:40Z","timestamp":1725343060397},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,2,13]],"date-time":"2009-02-13T00:00:00Z","timestamp":1234483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The cytologic findings of a clear\u2010cell pancreatic endocrine neoplasm (PEN) diagnosed by endoscopic ultrasound\u2010guided fine\u2010needle aspiration (EUS\u2010FNA) occurring in a 29\u2010year\u2010old man with von Hippel\u2010Lindau (VHL) syndrome are described. Imaging studies showed multiple pancreatic masses and cysts, a single liver lesion, and pulmonary and renal cysts. Cytologic features of this clear\u2010cell PEN included the presence of large sheets and rounded clusters of polygonal neoplastic cells with relatively abundant cytoplasm containing numerous, small, sharply\u2010demarcated vacuoles that occasionally indented nuclei and gave the cells a \u201cfrothy\u201d appearance. Mild anisonucleosis was present and nucleoli were visible. Rare single cells and stripped nuclei were seen. Small vessels transgressed tumor cell sheets. These cytologic findings are distinct from those of typical endocrine neoplasms, and bear resemblance to the cytologic features of renal cell carcinoma metastatic to the pancreas. To the best of our knowledge, this is the first detailed report of the EUS\u2010FNA cytologic findings of a clear\u2010cell PEN associated with VHL syndrome. We believe that the distinctive and characteristic cytologic features, together with immunohistochemical studies, can allow a preoperative cytologic diagnosis of this highly unusual pancreatic lesion and avoid possible confusion with other clear\u2010cell neoplasms in the pancreas, particularly metastatic renal cell carcinoma. Diagn. Cytopathol. 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.21032","type":"journal-article","created":{"date-parts":[[2009,2,13]],"date-time":"2009-02-13T21:06:38Z","timestamp":1234559198000},"page":"365-372","source":"Crossref","is-referenced-by-count":16,"title":["Endoscopic ultrasound\u2010guided fine\u2010needle aspiration diagnosis of clear\u2010cell pancreatic endocrine neoplasm in a patient with von Hippel\u2010Lindau disease: A case report"],"prefix":"10.1002","volume":"37","author":[{"given":"Anthony\u2010Osei F.","family":"Safo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebecca W.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selwyn M.","family":"Vickers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen 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