{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:10:06Z","timestamp":1761988206623},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2009,2,13]],"date-time":"2009-02-13T00:00:00Z","timestamp":1234483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2009,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Morphologic differentiation of breast carcinoma from nonmammary malignancies in fluid specimens can be a diagnostic challenge. Immunocytochemistry is often employed in the differential diagnosis. In this study, we evaluated the expression of mammoglobin (MGB1) in body\u2010cavity fluid specimens and compared its efficacy as a marker for metastatic breast carcinomas with that of gross cystic disease fluid protein\u201015 (GCDFP\u201015). Cell blocks from 40 fluid specimens were immunostained with monoclonal antibodies against MGB1 and GCDFP\u201015. They included 15 breast carcinomas and 25 nonmammary carcinomas (10 lungs, 10 ovaries, 3 gastrointestinal tracts, 1 kidney, and 1 urinary bladder). Positivity was defined as the presence of cytoplasmic staining in 10% or more carcinoma cells. Thirteen (87%) and seven (47%) breast carcinomas showed positive staining with MGB1 and GCDFP\u201015, respectively. Three (12%) nonmammary carcinomas (2 ovarian and 1 colonic) showed positive MGB1 staining; one (3%) nonmammary carcinoma demonstrated positive GCDFP\u201015 staining. The differences of MGB1 and GCDFP\u201015 staining between breast and nonmammary carcinomas were statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.05). Both MGB1 and GCDFP\u201015 are specific markers for metastatic breast carcinomas in cell block fluid specimens (88 vs. 96%). However, MGB1 is more sensitive than GCDFP\u201015 as a marker for metastatic breast carcinoma (87 vs. 46%). Diagn. Cytopathol. 2009. \u00a9 2009 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/dc.21039","type":"journal-article","created":{"date-parts":[[2009,2,13]],"date-time":"2009-02-13T21:07:03Z","timestamp":1234559223000},"page":"475-478","source":"Crossref","is-referenced-by-count":29,"title":["Diagnostic utility of mammaglobin and GCDFP\u201015 in the identification of metastatic breast carcinoma in fluid specimens"],"prefix":"10.1002","volume":"37","author":[{"given":"Z.","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gidley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Horton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Roberson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. E.","family":"Eltoum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Chhieng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,2,13]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1990.tb17804.x"},{"key":"e_1_2_1_3_2","first-page":"105","article-title":"Immunohistochemistry of a gross cystic disease fluid protein (GCDFP\u201015) of the breast. 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